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Sismin

Allergic drugs

Sismin（ Loratadine Tablets ）Indications: This product is used to treat perennial and seasonal diseases rhinallergosis 、 Allergic conjunctivitis 、 Chronic urticaria And others Anaphylactic reaction Symptoms and signs 。

Drug name: Sismin
Prescription medicine or not: no

Main indications: Perennial and seasonal rhinallergosis 、 Allergic conjunctivitis 、 Chronic urticaria And others Anaphylactic reaction Symptoms and signs
Drug type: Other H1 receptor blockers

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Composition

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Main ingredients: loratadine

Chemical name : 4 - (8-chloro-5,6-dihydro-11H-benzo [5,6] - cycloheptano [1,2-b] pyridine -11- Alkenyl ）-1- Piperidine carboxylic acid ethyl ester

Molecular formula: C twenty-two H twenty-three ClN two O two

Molecular weight: 382.88300

character

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This product is white or off white.

Action category

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This product is used for otorhinolaryngology and dermatology over-the-counter drugs drugs.

indication

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For mitigation rhinallergosis Relevant symptoms, such as Sneeze , runny nose Nasal itching 、 nasal congestion And eye itching and burning. After oral medication, nose and eyes Symptoms and signs It can be relieved rapidly. Also applicable to mitigation Chronic urticaria 、 Itchy dermatosis And others Allergic dermatosis Symptoms and signs of^[1] 。

Specifications

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Each tablet contains loratadine 10 mg.

Usage and dosage

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Oral.^[2]

Adults and children over 12 years old: 1 tablet (10 mg) once a day.^[2]

Children aged 2-12: weight>30kg, one tablet (10mg) once a day.^[2]

Weight ≤ 30 kg: once a day, half a tablet (5 mg) once.^[2]

Adverse reactions

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cardiovascular system : According to foreign literature reports, excessive use of this product may occur Q-T interval Extend or Ventricular arrhythmia , including syncope Of Torsade de pointes ventricular tachycardia 。

Weight gain is occasionally seen, Anaphylactic reaction (e.g.: Angioedema 、 Bronchospasm 、 Photosensitivity 、 itch 、 rash ）, and there are individual convulsions , benign Paresthesia 、 Myalgia / Arthralgia , edema, emotional disorder, insomnia nightmare , transaminase increase and hepatitis Report of. It is not clear whether most of the cases are directly related to Sismin. This product has no central sedation and anti choline Strong and long-term effect histamine H1 receptor antagonists 。 Because of its lasting effect, once a day can control allergic symptoms for 24 hours.

Animal experiment indicate, Reproductive function No impact, no Teratogenic effect When a large dose (40mg/kg) is given rabbit The embryo is non-toxic, but it is Rat Embryos have Toxic effect 。 In large sample population trials, there is no increase in embryo abnormalities. On lactation In the experiment conducted by Metabolites from breast milk But its concentration is very low.

In pregnant women and Lactating women It has not been found that there is potential harm to the developing fetus. Breastfeeding women must weigh the advantages and disadvantages under the guidance of doctors. It may occur after taking abnormally large doses Arrhythmia Some serious life threatening arrhythmias, such as Q-T interval prolongation and tip twist Ventricular tachycardia And other ventricular arrhythmias mainly occur in patients who take excessive doses. There are rare cases that show that torsade de pointes ventricular tachycardia can occur in patients with dosage of 20-30mg/day (2-3 times the recommended dosage).

In individual cases, severe Arrhythmia Lead by or associated with one or more syncope episodes. Therefore, in case of syncope in patients taking the drug, the drug should be stopped immediately and appropriate clinical examinations should be carried out, including electrocardiogram Check. In case of excessive poisoning, supportive therapy should be taken, including gastric lavage and emesis, and close ECG monitoring should be carried out. If the Q-T interval is prolonged, continue to monitor until the Q-T interval returns to normal. Appropriate antiarrhythmic therapy can be used, but antiarrhythmic drugs that can prolong Q-T interval should be avoided.

yes Renal insufficiency The patient's research shows that, Hemodialysis Clears are not added. Average plasma with its active metabolite when reaching steady state Peak concentration 3 ～ 5ng/ml. End half life 1~2 days. The metabolites of this product mainly pass bile Excretion through feces.

taboo

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It is forbidden for those who are allergic to the ingredients in this product.

Drug interaction

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Take at the same time Tong Kangzuo 、 Macrolide antibiotics 、 Cimetidine 、 theophylline Such drugs will increase the concentration of loratadine in plasma, so it should be used with caution. Other known inhibition Liver metabolism The drug should be carefully combined before the interaction with loratadine is clear.^[3] May occur if used together with other drugs Drug interaction For details, please consult a doctor or pharmacist.^[3]

Storage

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Protect from light and store in an airtight manner.

packing

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Aluminum plastic packaging, 6 pieces/board/box, 2 X 6 pieces/board/box^[4] 。

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