A scientific research institution in Paris, France
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Pasteur Institute of France was founded in 1887 as a private foundation for public welfare.Its function is to devote itself to scientific research on disease prevention and treatmenttrainAnd other public health behaviors.It is not only a basic biological research center, a post university teaching center (research and diagnostic training), but also a specialized biomedical center, an inpatient center for infectious diseases, and a center for tropical pathology and immune system diseases.Pasteur Institute includes a history exhibition hall, a science exhibition hall and a new scientific information center with the library as the main body.
The Pasteur Institute has 2500 staff in Paris.The 2003 budget is 168.7 million euros, which consists of three parts, of which the Pasteur Institute's self generated income is 61.5 million euros, accounting for 36.5%;€ 50.9 million, accounting for 30.1%;The government supports 56.3 million euros, accounting for 33.4%.
The Pasteur Institute has 24 branches around the world: some are in France and overseas territories;Others are distributed around the world: Cote d'Ivoire, Central Africa, Greece, Italy, Algeria, Tunisia, Morocco, Vietnam, Russia, Senegal, Madagascar, Iran, Cambodia, Romania, Cameroon, Bolivia and China.In October 2004, French President Chirac presided over the unveiling ceremony of the Pasteur Institute Shanghai Branch during his visit to China.
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(1) Basic biological research,
(2) The application of biomedicine and biotechnology,
(3) Teaching Center
(4) National Reference Center and International Health Organization Cooperation Center,
(5) Biological contract and license identification,
(6) Hospitals (often with international vaccine centers).
The Pasteur Institute has 100 research units or research groups, including 10 departments. They are:
Shanghai Pasteur Institute, Chinese Academy of SciencesThe unveiling ceremony was held on October 11, 2004, and was attended by President Chirac of France, Vice President Chen Zhu of the Chinese Academy of Sciences, Vice Mayor Tang Dengjie of Shanghai, and Director of the Pasteur Institute Philip Kurilski of France.
Shanghai Pasteur Institute first introduced Professor Du Wensheng, a famous French virologist, as its director. He once served as the head of P4 laboratory in Lyon, France.The Chinese director is Professor Zang Jingwu, an internationally renowned immunologist, who are outstanding scientists and have rich experience in managing international scientific research institutions.Shanghai Pasteur Institute implements the director joint responsibility system under the leadership of the Council and strives to build a public platform to provide infectious disease research for China and Shanghai.As a member of the global research and medical network of the Pasteur Institute, the scientists of the Shanghai Pasteur Institute will work with the world's top infectious disease experts to share the latest resources and research results, and strive to build a world recognized high-level research institution.
The purpose of Shanghai Pasteur Research Institute (preparatory) is to devote itself to the research in the field of infectious diseases in China, especially viral diseases, and serve the public health needs of China.Organize research on the combination of basic and clinical aspects of infectious diseases, create an education base focusing on graduate education and giving consideration to professional training at all levels, promote technological innovation and transformation of scientific and technological achievements, and serve public health in various ways.
Institute mission
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Frontier scientific research
Serve public health
Strict scientific education and training
Historical evolution
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On January 28, 2004, witnessed by Chinese President Hu Jintao and French Prime Minister Raffarin, Chen Zhu, Vice President of the Chinese Academy of Sciences, and Philip Kurilski, Director of the Pasteur Institute of France, signed a letter of intent for cooperation between the Chinese Academy of Sciences and the Pasteur Institute of France to establish the Shanghai Pasteur Institute.
In March 2004, the French delegation visited the Chinese Academy of Sciences
In May 2004, the delegation of the Chinese Academy of Sciences visited Pasteur Institute
On August 30, 2004, the Chinese Academy of Sciences, the Shanghai Municipal People's Government and the Pasteur Institute of France signed the establishmentShanghai Pasteur Institute, Chinese Academy of SciencesChen Zhu, Vice President of the Chinese Academy of Sciences, Yan Junqi, Vice Mayor of Shanghai, and Philip Kurilski, Director of the Pasteur Institute of France attended the signing ceremony.
On October 11, 2004, the Shanghai Pasteur Institute of the Chinese Academy of Sciences held its inauguration ceremony, which was jointly inaugurated by President Chirac of France, Vice President Chen Zhu of the Chinese Academy of Sciences and Vice Mayor Tang Dengjie of Shanghai.
After strict selection by the expert committee, in July 2005, the first group of four scientists were appointed as research leaders, and the laboratory was officially established in Shanghai Pasteur Institute.
In December 2006, the staff of the Pasteur Institute in Shanghai had a team of 72 people. The picture shows the board of directors taking a group photo with all the staff of the Institute.
In March 2023, the Pasteur Institute of France announced that it would suspend the cooperation agreement with the Chinese Academy of Sciences on the Pasteur Institute of Shanghai from December 2022.[1]
strategic target
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The values of the Chinese Academy of Sciences (science, democracy, patriotism, dedication; realism, truth-seeking, cooperation, innovation), and the "Pasteur concept" (high-level research, active participation in public health undertakings, and commitment to education and training) guide the actions and ethics of Shanghai Pasteur Institute to meet the needs of public health.
Shanghai Pasteur Institute is committed to contributing to the prevention and treatment of infectious diseases through research, participation in public health undertakings, education and training.Focus on the following activities:
Research on infectious diseases, especially major viral infectious diseases (AIDS, respiratory diseases, including SARS and avian influenza, hepatitis B and C, encephalitis, etc.)
Actively participate in public health undertakings, and make contributions to the improvement of efficient epidemic surveillance system and identification of new viruses through high-level research.
Build a biotechnology platform to provide services for the development of infectious disease diagnosis, vaccines and therapeutic drugs.
Training and education on infectious diseases and prevention and control of infectious diseases
In addition, we will carry out technology transfer in the future, transform research achievements into applications, and serve scientific research, including establishing business incubators and providing various technical services as needed.
Shanghai Pasteur Institute is committed to becoming an internationally advanced research institution in the field of infectious diseases.The research focus of Shanghai Pasteur Institute is first of all the diseases closely related to China, such as AIDS, SARS, influenza, hepatitis caused by hepatitis B virus and hepatitis C virus, as well as zoonosis, such as avian influenza, which poses the greatest threat to human health and life, andJapanese encephalitis。Shanghai Pasteur Institute has made important progress in basic and applied research of viruses, which has laid the foundation for it to become an advanced research center in the field of new viral diseases and their treatment and prevention.In the field of acute respiratory disease research, an international cooperative research alliance in the Asia Pacific region coordinated by the Pasteur Institute of France has achieved results.At the end of 2006, we launched the project of hepatitis and other tumor viruses, and carrying out new AIDS research projects will become one of the priorities in the next few years.
development direction
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The discipline strategic planning of Shanghai Pasteur Institute is based on scientific research on innovation and competition, and its main research directions are:
Molecular biology of viruses and mechanisms of infection and toxicity
Major human virusSexually transmitted diseasesThe basic biological problems include the following viruses: HIV, hepatitis B and C virus, coronavirus, influenza virus, arthropod borne virus;
Virus identification of new viral infectious diseases: mechanisms of virus invasion, replication and morphogenesis;
Molecular characteristics and regulation of RNA virus polymerase;
Virus host interaction, virus pathogenic molecular mechanism and tumorigenic mechanism.
Immune response and regulation mechanism of virus infection
Natural and adoptive immune response and regulation mechanism of virus infection;
The natural immune signal mechanism of virus infection, especially the intracellular MAP kinase pathway and TLR signal pathway;
Immunomodulation and new immunotherapy.
Research on new vaccines and disease prevention
Develop new vaccines for major viruses threatening public health based on the long-term immune response induced by inert molecules or live vectors of recombinant technology;
Establish appropriate animal models to carry out pathological and pre vaccine clinical studies.
Study on Microbial High Efficiency Expression System and Recombination Technology
Develop microbial high efficiency expression system and recombination technology, and study microbial structure andFunctional protein；
To study the relationship between structural viral protein and functional viral protein;
applicationHigh throughput screeningTechnology, screening antiviral molecules from traditional Chinese medicine.
Establish an advanced biomolecular platform
Shanghai Pasteur Institute has built or will build a new diagnostic technology, vaccine and drug research platform:
"Human Viromics" platform, includingBiosafety laboratoryCell culture technology, multiple, real-time PCR, biochip, can cause serious virusSexually transmitted diseasesRapid identification of pathogens by sequencing technology;
A biotechnology platform based on lentivirus pseudovirus particles to carry out virus cell interaction, invasion and morphological characteristics, virus stability, and high-throughputAntiviral drugsBasic research such as screening or neutralizing antibody titration test;
Establish a high-level aseptic animal experimental center for the reconstruction of human cellsSCID mouse To provide experimental basis for preclinical experiments.
Cooperative research
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1. With the strength of the international network of the Pasteur Institute and the international cooperation relations established by researchers with international backgrounds, Shanghai Pasteur Institute has carried out extensive international cooperation.In 2005, eight Pasteur Institutes in the Asia Pacific region decided to launch the RESPARI project (research based coping mechanism for acute respiratory infections).The project has formed a unique alliance of mutual promotion and cooperation among the international scientific community, and has received suggestions and support from the International Committee of Science and Experts.All research institutes share technology, reagents and biological products in the fields of clinical and epidemic, diagnosis, vaccine and antiviral research related to respiratory virus infection.
2. In 2006, Shanghai Pasteur Institute participated in two EU research projects on avian influenza, namely FLUNNATE (Research on Inherent Respiratory Immunity of Mammalian Influenza Virus Infection) and RIVERS (Research on Influenza Virus Resistance in Environmental Hosts and Systems).These two projects will help our researchers reach the international advanced level in the field of avian influenza research in the shortest time.
3. Shanghai Pasteur Institute and France Pasteur Institute have established horizontal cooperationJapanese encephalitisAnd West Nile yellow virus.This research project will open up a new way to research and develop a stable attenuated live virus vaccine.Shanghai Pasteur Institute has established cooperation with Japan in the field of hepatitis C and influenza virus research.betakeRNA genomeStudy on the Recombination Technology of Polymerase Complex Deconstruction.The goal of this project is to understand the mechanism of virus pathogenicity and develop anti-virus strategies
Management Committee
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The management committees of Shanghai Pasteur are composed of scientific researchers and managers, respectively, to manage scientific research, graduate education, public laboratories and public equipment, biosafety, finance, infrastructure and other affairs.Each management committee is responsible to the director's office meeting.Academic Exchange Committee
Director: Zhou Baobao
Members: Du Wensheng, Sun Bing, Lan Ke, Zhong Jin, Toyoda Zheya, Leng Qibin, Chen Rong, Li Bin, Huang Zhong, Zhang Yan, Wang Jianhua
Secretary: Ye Pingyang (academic), Wu Ning (talent recruitment)
Responsibilities: - Guide the academic exchange activities of the Institute-Review and guide the ethical issues involved in the scientific research of the Institute-According to the regulations and budget of the Institute, review and approve the plan to invite well-known scholars at home and abroad to make academic reports. - The director of the Academic Committee represents the Institute to participate in the regular meetings of the Academic Committee of the Academy of Sciences-Review the introduction of research team leaders, associate professors and above;Review the qualifications of candidates and propose a list of invited candidates for interview.
Academic Degree and Graduate Education Committee
Director: Zhong Jin
Members: Du Wensheng, Sun Bing, Lan Ke, Zhou Baobao, Toyoda Zheya, Leng Qibin, Chen Rong, Li Bin, Huang Zhong, Zhang Yan, Wang Jianhua
Secretary: Wu Ning, Lan Ying
Responsibilities: - Formulate the postgraduate training plan of the Institute according to relevant regulations;Formulate regulations for graduate tutors of the Institute, review the qualification of graduate tutors of the Institute and report to the superior competent department;In accordance with the relevant regulations, formulate the standards for degree awarding of the Institute;Be responsible for evaluating the graduate degree of the Institute and reporting to the superior competent department?The Director of the Education and Academic Degrees Committee represents the Institute to attend the regular meetings of the Academic Degrees and Education Committee of the College of Biological Sciences and Shanghai Branch.
Public Laboratory and Public Instrument Management Committee
Director: Toyoda Zheya
Members: Du Wensheng, Sun Bing, Lan Ke, Zhou Baobao, Zhong Jin, Leng Qibin, Chen Rong, Li Bin, Huang Zhong, Zhang Yan, Wang Jianhua
Secretary: Lu Zhizhao, Gao Hongxiang
Responsibilities: - Discuss and propose suggestions on the selection, bidding and purchase of large-scale public instruments and equipment, and report to the Research Institute for approval.-Discuss and decide the management plan of public instruments and equipment-Establish management regulations for public laboratories
Biosafety Committee
Director: Du Wensheng Members: Toyoda Zheya, Sun Bing, Lan Ke, Zhou Baobao, Zhong Jin, Leng Qibin, Chen Rong, Li Bin, Huang Zhong, Zhang Yan, Wang Jianhua
Executive team: Gao Xuan, Lu Zhizhao, Jia Jinhua, Zhou Jing, Wang Lu, Mo Xiaowei
Responsibilities: - From a scientific perspectiveBio-SafetyManagement makes suggestions-Participate in the formulation of biosafety management rules and regulations of the Institute-According to Chinese regulations and risk assessment standards, the samples of biological experimentsBiosafety levelPut forward suggestions - examine and approve the experimental operating procedures related to infected samples, experimental animals, DNA recombination, and genetically modified micro-organisms-Formulate and revise the biosafety management regulations and operating procedures of the Institute-Responsible for biosafety training of the Institute-Supervise the implementation and implementation of the Institute's biosafety management regulations and operating proceduresBiological hazardEvaluation of degree;Authorization to enter P2/P3 of the Institute-Formulate laboratory accident prevention measures and emergency plans, coordinate with relevant departments to ensure the biological safety of the Institute;Be responsible for the emergency handling of biosafety accidents in the laboratory of the unit and timely report to the relevant superior management departments-Arbitration of biosafety incidents and accidents in the Institute.
Finance and Partners Committee
Director: Jiang Weihong
Deputy Director: Lu Heping Member: Dong Jun
Responsibilities: to make suggestions and advice to the director's office meeting in terms of funds and human resources.
Infrastructure Committee
Director: Jiang Weihong
Deputy Director: Lan Ke
Members: Lu Heping, Lu Zhizhao, Gao Hongxiang, Jia Jinhua
Responsibilities: organize the implementation of P3 laboratory construction;Contact and coordinate the construction of the new laboratory building of Pasteur Institute on Yueyang Road;Ensure the normal operation of infrastructure in different parks of the Institute.
Shanghai Pasteur Institute, Chinese Academy of SciencesIt is a research institution established in accordance with the General Agreement on Cooperation signed by the Chinese Academy of Sciences, Shanghai City and the Pasteur Institute of France on August 30, 2004.It started operation in July 2005.The current director is researcher Du Wensheng, and the joint director is researcher Sun Bing.purpose
According to the national public health needs, make contributions to the prevention and treatment of infectious diseases through application-oriented basic research, public health services and education.Postgraduate education includes the cultivation of master's and doctoral students, and the training of professionals. Combining the resource advantages of the international network of the Chinese Academy of Sciences and the Pasteur Institute, efforts are made to create an international education and training environment, and cultivate high-quality innovative talents for the biomedical community.
Main tasks
Infectious diseases (especially viruses)Sexually transmitted diseasesIncluding the pathogenesis of AIDS, respiratory diseases such as SARS, avian influenza, hepatitis, encephalitis, etc.);Based on basic research, develop the application technology required by public health undertakings, and establish a biomedical technology platform;Develop new diagnostic technologies, preventive vaccines and therapeutic drugs;Carry out education and training activities on infectious diseases and their prevention and control knowledge;Establish business incubators to put research results into practical application.
Discipline layout
Shanghai Pasteur adheres to its mission and strives toMolecular virologyAnd antiviral immunization to become a world-class research institution, contributing to the prevention and control of infectious diseases.The strategic direction of research mainly focuses on basic research and transformational research:
-Immune response mechanism and viral infection regulation;
-Research and development of new vaccines.
Scientific research team and talent cultivation
The Institute has 117 staff (as of December 2008).There are 101 scientific researchers, including 11 researchers, 3 associate researchers, 37 research assistants/assistant researchers, 49 graduate students, 2 post doctors, and 10 management personnel and 6 technical support personnel.
The graduate education of the Institute includes the cultivation of master's and doctoral graduates. Combining the resource advantages of the international network of the Chinese Academy of Sciences and the Pasteur Institute, the Institute strives to create an international education and training environment and cultivate high-quality innovative talents for the biomedical industry.
Scientific research achievements
Pasteur Institute and other scientists have revealed an anti-inflammatory mechanism involved in perception and regulation of different brain regions
In 2023, scientists from the Pasteur Institute, the French National Science Research Center and the National Institutes of Health and Medicine revealed a new circuit involved in sensing and regulating anti-inflammatory responses in different regions of the brain, opening a new era for research in neurobiology and immunologyDoors.[2]
