4-aminobenzoic acid, also known as p-aminobenzoic acid, is an organic compound with the chemical formula CsevenHsevenNOtwoIt is a white crystalline powder, easily soluble in hot water, ether, ethyl acetate, ethanol and glacial acetic acid, insoluble in water, benzene, and petroleum ether. It is mainly used as medicine and dye intermediates, as well as analytical reagents and sunscreen agents.
On October 27, 2017, the list of carcinogens released by the International Agency for Research on Cancer of the World Health Organization (WHO) was preliminarily sorted out for reference, and p-aminobenzoic acid was included in the list of category 3 carcinogens.[1]
Solubility: soluble in hot water, ether, ethyl acetate, ethanol and glacial acetic acid, insoluble in water, benzene, insoluble in petroleum ether[2]
Molecular structure data
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Molar refractive index: 37.41
Molar volume (cmthree/mol）：104.2
Isotonic specific volume (90.2K): 295.2
Surface tension (dyne/cm): 64.3
Polarization (10-24cmthree）：14.83[2]
Calculate chemical data
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Reference value for drainage parameter calculation (XlogP): None
Number of hydrogen bond donors: 2
Number of hydrogen bond receptors: 3
Number of rotatable chemical bonds: 1
Number of tautomers: 3
Topological molecular polar surface area: 63.3
Number of heavy atoms: 10
Surface charge: 0
Complexity: 128
Number of isotope atoms: 0
Determine the number of atomic structure centers: 0
Number of uncertain atomic structure centers: 0
Determine the number of chemical bond structure centers: 0
Number of uncertain chemical bond structure centers: 0
Number of covalent bond units: 1[2]
toxicology data
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Acute toxicity: oral LD in ratsfifty：>6 gm/kg；Abdominal LD of ratsfifty：>3450 mg/kg；Mouse oral LCfifty：2850 mg/kg；Rabbit oral LDfifty：1830 mg/kg。[2]
purpose
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It is mainly used as intermediate of medicine and dye, as well as analytical reagent and sunscreen agent.
First aid measures
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Skin contact: Take off contaminated clothes and wash with flowing water.
Eye contact: Lift the eyelid and flush with flowing water or physiological saline.Get medical attention.
Inhalation: leave the site to fresh air.If breathing is difficult, give oxygen.Get medical attention.
Ingestion: drink enough warm water to induce vomiting.Get medical attention.
Leakage emergency treatment
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Isolate the leakage contaminated area and restrict access.Cut off the ignition source.It is recommended that emergency personnel wear dust masks (full face masks) and gas suits.Avoid flying dust, sweep it carefully, put it in a bag and transfer it to a safe place.In case of large leakage, cover it with plastic cloth and canvas.Collect and recycle or transport to waste disposal site for disposal.
Handling and storage
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Operation precautions: closed operation, local exhaust.Operators must be specially trained and strictly abide by the operating procedures.It is recommended that operators wear self-priming filter type dust mask, chemical safety goggles, anti poison penetration work clothes and rubber gloves.Keep away from kindling and heat sources, and smoking is strictly prohibited in the workplace.Use explosion-proof ventilation systems and equipment.Avoid dust generation.Avoid contact with oxidants.Load and unload gently during transportation to prevent damage to packaging and containers.Fire fighting equipment and leakage emergency treatment equipment of corresponding types and quantities shall be provided.Empty containers may leave harmful substances.
Precautions for storage: store in a cool and ventilated warehouse.Keep away from kindling and heat sources.Keep container sealed.It shall be stored separately from oxidant and shall not be mixed.Equip with corresponding types and quantities of fire-fighting equipment.The storage area shall be equipped with appropriate materials to contain leakage.
security information
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Safety terminology
S26：In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
In case of contact with eyes, please immediately flush with plenty of water and seek medical advice.
S36/37/39：Wear suitable protective clothing, gloves and eye/face protection.
Wear appropriate protective clothing, gloves and eye/face protection.
Risk terminology
R36/37/38：Irritating to eyes, respiratory system and skin.
