Pyrimidine, also known as 1,3-diazabenzene, is aHeterocyclic compound, chemical formula is CfourHfourNtwo。Pyrimidine consists of 2Nitrogen atomreplacebenzene2 on intermolecular positioncarbonFormation is a kind of diazine.andpyridineSimilarly, pyrimidine remainsAromaticity。
Used as raw materials for pharmaceutical intermediates and photosensitive agents
Effective content
4%
Specifications
100ml； 200ml
Physical and chemical properties
The original drug is white powder in appearance, melting point 165-167 ℃ (decomposition), easily soluble in water, insoluble in organic solvents, low toxicity, acute oral: 124.4mg/kg, stable in acidic and neutral media, unstable in alkaline media.[2]
usage method
Spray 1000-1500 times diluted liquid on the leaf surface
Five types of DNA and RNABaseAmong them, three are pyrimidine derivatives:cytosine （Cytosine），Thymine（Thymine），Uracil(Uracil) thymine can only appear in deoxygenationRiboseIn nucleic acid, uracil can only appear inRibonucleic acidMedium, and cytosine can be both.staycomplementary base pairing Thymine (in DNA) or uracil (in RNA)purineWith two hydrogen bonds, cytosine andGuanineIt is bound by three hydrogen bonds.
A kind of basic nitrogenHeterocycleOrganic compound。Its derivatives such as cytosine, uracil, thymine are important components of nucleic acids.Bit 1 and 3 contain 2 impuritiesatomSix yuan ofHeterocyclic compound。Refractive index 1.4998.Soluble in water and ethanol.It has a bad smell.It is a water-soluble weak base, pKa 1.3Mercuric chlorideForming slightly soluble molecular compounds.
PyrimidinePicrate, melting point 156 ℃;oxalateMelting point 160 ℃.Difficult to carry outElectrophilic substitution reaction。Pyrimidine derivatives are widely found in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings.AndPyrazineandPyridazineMutualIsomer。With picric acid andoxalateA yellow crystalline substance is formed.Pyrimidine and its derivativeshomologueIt is aromatic with nitro and halogenated derivatives.Oxidation and electrophilicitySubstitution reactionInactive.Nucleophilic reactionNot significant, only 4-methylpyrimidine canSodium aminoThe reaction yields 2 or 4 substituted aminopyrimidines.[2]
application
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(1) Anticancer drugs.For the selection of anticancer substances, it is essential that they have significant differences between tumor tissue and normal tissue, that is, they have certain recognition ability for target cells.porphyrin compound With its unique structure, it has special affinity to cancer cells, and can selectively stay in cancer tissue.As a tumor targeting agent and a drug for diagnosis and treatment, it has attracted great interest of chemists, physicians and biologists.5-FluorouracilIt is an antimetabolic and anti-tumor drug widely used in clinic, which has inhibitory effect on many kinds of tumors, and has good clinical effect in treating many kinds of cancers such as intestinal cancer, gastric cancer, breast cancer, etcpolyester, polyester hydrocarbon, polyester amideDeoxyribonucleic acid、furan、Nitroxide radicalThe connected 5-fluorouracil derivatives have anti-tumor effects.In order to reduce its toxic and side effects, people have carried out a lot of modification work on 5-fluorouracil, and achieved certain results.For example, the introduction of short peptides, glucose, nitrogen oxygen free radicals, etc.WhereasPorphyrin compoundsIt can selectively stay in cancer cells andMalignant tumorTissue has special affinity and other characteristics. It can be used to transport 5-fluorouracil to cancer tissue to kill cancer cells and reduce damage to normal cells.Monosubstituted and disubstituted chlorophenylporphyrin-5-fluorouracil compounds, and some 5-fluorouracil compoundsHela cells(Cervical cancer cell) has obvious inhibitory effect, but its water solubility is poor.Three new pyridine porphyrin 5-fluorouracil compounds were synthesized by linking pyridine N of pyridine porphyrin with 1 - (3-bromopropyl) - 5-fluorouracil to form pyridine quaternary ammonium salt.As an antineoplastic drug, uramustine has a good therapeutic effect on breast cancer, lymphosarcoma, multiple myeloma and other malignant tumors.Developed and listed by Meadohnson in 1985Buspirone hydrochloride(BuspiHydro chloride) has good anti anxiety use and can be used as an activator of 5-HTA part to treat acute and chronic anxiety.This product has the characteristics of high selectivity, exact curative effect and little addiction.Developed and listed by Japan Hongyao Pharmaceutical Strains Association in 1980Nimustine hydrochlorideWound (Justine Hydr chlorride) is an effective anti-tumor drug.It is used to relieve brain tumors, gastrointestinal tumors (stomach cancer, liver cancer, colorectal cancer), lung cancer, malignant lymphoma, leukemia and other diseases.
(2) Anti AIDS drugs.Viral diseases have become one of the most harmful diseases to human beings, especially the spread of AIDS, which has aroused widespread concern.There are many kinds of anti AIDS drugs approved for marketing by the US Food Administration (FDA), many of which are nucleoside compounds.In order to reduce the toxicity of drugs and improve the efficacy, scientists began to focus on the research of non nucleoside compounds, which have becomeAntiviral drugsResearch focus.The compounds that have entered the clinical research stage of AIDS mainly include bis (heteroaryl) piperazine, bis (heteroaryl) piperazine (representative compound U87261), TI-BO, TSAO (representative compound TSAO-T), nevirapine bipyridine (representative compounds L-697, L-661), 1 - [(2-hydroxyethoxy) methyl] - 6 - (phenylthio) thymine (HEPT) andAcyclovirEtc.After extensive structure-activity relationship research, synthesis and screening, it was found that some HEPT like compounds have strong HIV virus inhibitory effects, small side effects, and extensive anti drug effects.Although HEPT, as a non nucleoside drug, has low toxicity and high efficiency, it will still produce eczema, elevated transaminase and other toxic side effects when used in large doses in clinical for a long time. Therefore, in order to increase efficacy, reduce side effects, and avoid HIV drug resistance, HEPT is often used in combination with commonly used anti AIDS drugs such as AZT, DDI, DDC, and carbocyclic guanosine.[1]
Functional features
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This product is an efficient, broad-spectrum biological bactericide, with dual effects of prevention, protection and internal absorption treatment;The protective ingredients of this product can form a dense polymer protective film on the surface of plants and fruits, which has a strong inhibitory and blocking effect on a variety of pathogens;The therapeutic ingredients can reach the interior of the fruit through the transmission of branches and trunks, directly blocking the synthesis of pathogenic proteins, leading to their death.This product has dense protection and strong internal absorption. It is not easy to produce drug resistance when used continuously. Even in rainy seasons, it can still maintain a strong internal absorption effect.
Spray on leaves or fruits of crops in the evening, avoiding hot sun and rainy days
The content of this product is very high, and it can be used as needed. Please prepare it according to the use concentration
Warm reminder: Please reserve a space for spraying to better test the effect of this product.[2]
Safety terminology
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S16 Keep away from fire sources.
S23 Do not breathe vapor.
S24/25 Avoid contact with skin and eyes.[1]
synthetic method
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pyrimidine
There are many ways to synthesize pyrimidine and various substituted pyrimidines.For example,Barbituric acid(2, 4, 6-threeHydroxypyrimidine）Can be determined by urea andDiethyl malonatestaySodium alkoxideIt is condensed under the action of.Barbituric acid and phosphoryl chloride are heated together to obtain 2,4,6-trichloropyrimidine, which is mixed withSodium methoxideReaction, and trimethoxypyrimidine can be obtained.The chloropyrimidine reacts with ammonia or primary and secondary amines to generate corresponding aminopyrimidine.The derivatives of pyrimidine, cytosine, uracil and thymine, are nucleic acids andDeoxynucleic acidComponents of,Vitamin B1The pyrimidine part of the molecule is a 4-amino-2-methyl-5-pyrimidine methyl group.Many oral long-acting sulfa drugs are derivatives of pyrimidine and its isomers.
