This disease is considered ascml It is also classified as hypereosinophilic syndrome.Clinical exclusionleukemiaIn addition, eosinophils infiltrated various organs.Small after myocardial infiltrationArterial embolism, fibrosis,scarNecrosis.The formation of wall thrombus may cause myocardial damageCardiomegaly、ArrhythmiaAnd progressive hyperemiaheart failure。The latter is oftenCause of death。Lung infiltration may occurcough、dyspneaEtc;X-rayCheck the visible bilateralLung fieldpresentTransitoryMesh shadows.central nervous systemyesMental disorders, delusionAtaxia, convulsion, paralysis, coma, etc.The skin shows erythemapapule, skin summary, etc.2/3 patientswhite blood cellAbove 50000/mm3, in which eosinophils account for 60%~85%.originalCellular typeIn addition to protoeosinophils,ProgranulocyteAlso increased;Immature cellType A is mainly young acidophileGranulocytosis, may also be accompanied by an increase in neutrophils;The mature cell type is only mature eosinophils increased.Eosinophils may present enlarged granules and uneven distribution,CytoplasmThere are vacuoles, excessive nuclear lobulation, etc.NeutrophilsOfalkaline phosphataseNormal, in bloodlysozymeNo increase.Chromosomes may have aberrations, which may occur individuallyPh chromosome。For primitive and immature cell types, the treatment is like acute granulation, which is used by individual patientsvincristine、HydroxyureaandAdrenocortical hormoneAlso valid.
