Sialic acid Sialic acid is a derivative of 9-carbon monosaccharide.The name comes from the Greek (σ I α λ o σ (sialos) 'saliva'), which is a negatively charged ion that can make saliva smooth.It not only has the function of "inducing" invading bacteria, but also cognition is the neurotransmitter of gangliosides and a part of the brain.
Sialic acid (SA), scientific name is "N-acetylNeuraminic acid”, is a natural existencecarbohydrate。It was originally created bysubmaxillary gland mucin It is also named for its separation from.Sialic acid is usually composed of oligosaccharides,GlycolipidsperhapsglycoproteinExists in the form of.In human body, brain has the highest content of sialic acid.The content of sialic acid in brain gray matter is 15 times that of liver, lung and other internal organs.The main food source of sialic acid is breast milk, which also exists in milk, eggs and cheese.
Chinese name: N-acetylneuraminic acid
English name: N-Acetylneuraminic acid
Alias name: sialic acid acetoniularate N-acetylmannosamine pyruvate N-acetylsialic acid
Solubility: soluble in water and methanol, slightly soluble in ethanol, insoluble in ether, acetone and chloroform.[2]
toxicology data
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Acute toxicity: main irritant effect: on the skin: may cause inflammation.Above the eyes: May cause inflammation.Sensitization: no sensitization effect.[2]
Ecological data
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Water hazard level 1 (German regulation) (self-assessment through the list) The substance is slightly harmful to water.
Do not allow undiluted or large quantities of products to come into contact with groundwater, waterways or sewage systems.
Do not discharge materials into the surrounding environment without government permission.[2]
11. Determine the number of atomic structure centers: 6[4]
12. Number of uncertain atomic structure centers: 0[4]
13. Determine the number of chemical bond structure centers: 0[4]
14. Number of uncertain chemical bond structure centers: 0[4]
15. Number of covalent bond units: 1[2]
Properties and stability
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Avoid inhaling the dust of this product, and avoid contact with eyes and skin.[2]
Storage method
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It shall be sealed with argon gas and stored in dry condition at - 18 ℃.[2]
purpose
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For tissue culture.Biochemical research.
security information
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Safety sign: S22S24/25[2]
Medical research
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In medicine, glycolipids containing sialic acid are calledGangliosideIt plays a very important role in the generation and development of the brain and nervous system.At the same time, animal experimental research shows that the decrease of ganglioside level is associated withinnutritionIt is related to the decrease of learning ability, and the supplement of sialic acid can improve theLearning behavior。Adequate sialic acid supply for lowbirth weight The normal development of children's brain function may be particularly important.After the baby is born, the sialic acid in the breast milk is crucial to ensure their normal development.The survey shows that the level of sialic acid in the mother's body after delivery has a downward trend over time.Therefore, continuous intake of sufficient sialic acid during and after pregnancy can help maintain the level of sialic acid in the body.Moreover, the content of sialic acid is also significantly related to the content of DHA, which indicates that it is very likely to be related to the development of brain structure and brain function of infants, and both may be beneficial to early brain development.
[Clinical significance] Sialic acid is N-AcetylneuramineAcid or any ester or alcohol thereofhydroxylA derivative of, located at the end of the glycoprotein side chain of the cell membrane, is the cell membraneSurface receptorAn important part ofInflammatory diseaseandMalignant tumorThe increase in disease, such as lung cancer, stomach cancer, bowel cancer, liver cancer, ovarian cancer.[3]
