South China State Key Laboratory of Oncologyrely onSun Yat-sen UniversityAt the end of 2004, according to the discipline developmentTumor BiologyWith the approval of the Ministry of Science and Technology, the South China National Key Laboratory of Oncology was established on the basis of the Key Laboratory of Tumor related Genes and Antitumor Drugs Research of the Ministry of Education, the Key Laboratory of Nasopharyngeal Cancer of Guangdong Province and the National Clinical Trial and Research Center for New Drugs (Antitumor Drugs)Shanghai Cancer Institute"State Key Laboratory of Oncogenes and Related Genes" andChinese Academy of Medical Sciences“State Key Laboratory of Molecular Oncology”Then there was another national key laboratory of oncology, and it was also the first national key laboratory of medical science of Sun Yat sen University,
As one of the earliest cancer specialized institutions in China, the hospital has become an important medical teaching and research base of oncology in China, a World Health Organization Cancer Cooperative Research Center, a national key discipline of oncology, and a national clinical trial and research center for new drugs (anti-tumor drugs).In 2002, the "Key Laboratory of Tumor Related Genes and Antitumor Drugs Research of the Ministry of Education" was established.After several years of construction, breakthroughs have been made in the research of tumor susceptibility genesclinical diagnosisNew anti-tumor drugs and biological therapy have a good working foundation.In March 2006, our laboratory participated in the evaluation of the National Key Laboratory of Life Sciences organized by the Ministry of Science and Technology for the first time and was rated as a good laboratory.It was accepted by the Ministry of Science and Technology in November 2008.
Overall positioning
Announce
edit
Utilize the disease resources in Guangdong and the unique resources of traditional Chinese medicine in the south, give full play to the characteristics of the close combination of clinic and foundation, reveal the mystery of tumor occurrence and development, especially nasopharyngeal carcinoma, research new means of early diagnosis of tumor and new anti-tumor drug precursors, improve the level of tumor diagnosis and treatment, and improve the life and health of tumor patients;Gather a group of internationally influential academic leaders to become a base for cultivating high-quality talents and producing original innovative achievements;It has become an academic exchange center of oncology at home and abroad and an open laboratory with international advanced level.
Talent team
Announce
edit
The laboratory now has 51 personnel, including 2 academicians of the Chinese Academy of Sciences, 37 professors, 34 doctoral supervisors, 4 winners of the National Science Fund for Distinguished Young Scholars, 4 winners of the New Century Excellent Talents Support Program of the Ministry of Education, 6 winners of the Hundred Talents Program of Sun Yat sen University, 32 of whom have doctoral degrees, 10 heads of national academic organizations, and 8 chief editors and deputy chief editors of national core journals,Most of the academic leaders and academic backbones in the discipline are young, energetic and innovative at the age of 40, and have made outstanding achievements in their respective research majors.
Scientific research conditions
Announce
edit
The laboratory is located in the supporting unitCancer Center of Sun Yat sen UniversityIn the medical research building, the laboratory covers an area of 3360 square meters, with totally enclosed central air conditioning, automatic logistics lines and intelligent management systems. The laboratory is composed of a public service area and 20 independent experimental suites. It also has a laminar flow purification biological treatment laboratory and a GCP laboratory that meet GMP standards.The public service area includes large centrifuge room, ultra-low temperature refrigerator room, cold room, purified water supply room, washing room, darkroom, specimen bank and public instrument room.The public instrument room is equipped with laser confocal microscopeFlow cytometry, genetic analyzer, fluorescence quantitative PCR instrument, full-automatic control cell culture tank, image analysis micro spectrophotometerMultifunctional microplate readerLaser micro cutting instrumentHigh performance liquid chromatographyFluorescence inverted microscopeUltraviolet spectrophotometerAnd other large-scale public instruments.The independent experimental suite is composed ofcell cultureRoom, fume hood, experimental operation room and the subject are responsible for the composition of the manual work room.
Scientific research achievements
Announce
edit
In the past few years, the State Key Laboratory of South China Oncology has made some gratifying achievements through the efforts of scientific researchers, using the scientific research conditions and management system of supporting units.Many results have a certain impact on the international community.For example, for the first time, the susceptibility gene of nasopharyngeal carcinoma was located on chromosome 4, and it was found that the promoter mutation of one of the genes was linked to the pathogenesis of nasopharyngeal carcinoma (this achievement was awarded in 2005National Natural Science AwardSecond prize);The N1 subphase in lymph node staging was found, the rule of primary invasion and neck lymph node metastasis of nasopharyngeal carcinoma was found, the survival value of radiotherapy supplemented with concurrent chemotherapy was clarified, and prognostic indicators and new therapeutic targets were found. The promotion and application of this technology improved the five-year survival rate of nasopharyngeal carcinoma patients from 61.2% to 73.3% (this achievement was awarded in 2009National Science and Technology Progress AwardSecond prize);Adenovirus mediated endostatin injection has been approved by the State Food and Drug Administration for clinical trial and has been completedPhase I clinical trial；Some new multidrug resistance reversal agents and small molecule targeted anti-tumor drugs were found and transferred to pharmaceutical enterprises for development;Complete the whole gene sequencing of Epstein Barr virus associated with nasopharyngeal carcinoma in Guangdong, and found some unique variations;Complete the development of artificial esophageal biomaterials and enter clinical trials.These studies have been cited and applied many times internationally.In addition to improving China's research level in gene cloning of complex diseases, new anti-tumor drugs, biomaterials and other aspects, the progress of laboratory work in these aspects can also provide a basis for early diagnosis of tumors and development of new drugs, and promote the development of tumor diagnosis and treatment in China.
Since 2005, it has won 103 new funds, including the 863 major projects during the 11th Five Year Plan period, the 863 projects during the 11th Five Year Plan period, the national key science and technology projects during the 11th Five Year Plan period, the National Science and Technology Fund for Distinguished Young Scholars, and the key projects of the National Natural Science Foundation of China. It has published 211 papers included in SCI, including J Clin Oncol,Cancer Res, Clinical Cancer Res, Oncogene, Leukemia, J Virol, Blood and other internationally renowned magazines won one second prize of the National Natural Science Award in 2005, one second prize of the National Science and Technology Progress Award in 2009, 34 patents were applied, 17 were authorized, and 6 monographs were edited.Since 2005, 114 doctoral students and 148 master students have been trained;There are 127 doctoral students and 79 master students.
management system
Announce
edit
The laboratory tried to implement the director responsibility system under the leadership of the unit. Under the guidance of the direction and goal of laboratory construction, it established and improved the technical platform, established the access system of the laboratory, integrated the essence of related disciplines, implemented the sharing of public equipment and technical platforms in the laboratory, and implemented the project leader system, the operation mechanism based on the project team.Set up open projects, director funds, etc., to attract outstanding scientific and technological talents at home and abroad, carry out international and domestic cooperation and academic exchanges, and support the initiation of innovative topics, new research directions, and the cultivation of outstanding young talents.
