The State Key Laboratory of Medical Molecular Biology (Institute of Basic Medicine, Chinese Academy of Medical Sciences) is the only comprehensive development laboratory in the field of medical research in China, located in the Institute of Basic Medicine, Chinese Academy of Medical Sciences.
Chinese name
State Key Laboratory of Medical Molecular Biology (Institute of Basic Medicine, Chinese Academy of Medical Sciences)
State Key Laboratory of Medical Molecular Biology[1]Relying on the Institute of Basic Medicine of the Chinese Academy of Medical Sciences, the laboratory was established under the guidance of the national long-term scientific and technological development plan and in combination with the characteristics of medical research.As it is located in the central area of Beijing, it is also associated with the library of the Chinese Academy of Medical Sciences, which has a rich collection of books and a long history, and the internationally famous large general hospital——Peking Union Medical College HospitalAdjacent to each other, it has a special and excellent environment for the development of basic medical research.
The State Key Laboratory of Medical Molecular Biology was invested about 2 million yuan by the Chinese Academy of Medical Sciences and rebuilt on the original site of the Institute of Zoology, covering an area of about 1500 square meters.It passed the expert argumentation on February 25, 1991, and in April 1992, the Ministry of Health issued a document to officially approve the implementation of the establishment and opening up of the system;In November 1993, it passed the acceptance organized by the State Planning Commission;In 1996 and 2001, it passed the expert evaluation organized by the National Science and Technology Commission twice, and both of its achievements were among the best in Level B.
After the completion of the new scientific research and teaching building of Peking Union Medical University in 2003, the key room was moved in, covering an area of 3800 square meters, making it more of a modern laboratory, providing a good scientific research environment for carrying out basic research in medical molecular biology and receiving advanced studies and open topics from international researchers,It provides a guarantee for the laboratory to better complete the tasks of undertaking major international scientific research projects and cultivating talents.
The foundation of this laboratory is the originalPeking Union Medical College(Peking Union Medical College) Department of Biochemistry has been engaged in molecular biology research in protein, nucleic acid and other related important fields for more than 40 years since the early 1950s. It has accumulated rich experience and trained a large number of research talents.In recent years, with the support of relevant departments, we have actively carried out international and domestic academic exchanges and cooperation, and gradually formed a research team with advanced equipment, strong technical force, advanced biological technology and methods, and young and middle-aged scientists as the backbone under the support of domestic and foreign multi-channel funds.There are 25 researchers and associate researchers (fixed staff) in this room, including 3 academicians of the Chinese Academy of Sciences, 2 academicians of the Chinese Academy of Engineering, and 18 doctoral supervisors. It has formed its own research characteristics, has high-level academic leaders in various research directions, and has become a leading laboratory in China and has a certain influence in the world.
The laboratory implements the director responsibility system, and the current director is Academician Liu Depei.The laboratory implements the evaluation system of academic committee, which is responsible for the examination and approval of laboratory research direction, construction planning, research topics, achievement evaluation and fund use principles.Two thirds of the members of the Academic Committee are outdoor experts with a term of office of three years. The current director of the Academic Committee is academician John Boqin.
Research direction
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Medical molecular biology studies the structure, function, interaction rules of biological macromolecules and their effects on cells and the whole under the normal and disease conditions of the human body. It intersects with medical foundation and clinical multidisciplinary, and becomes one of the most active fields in molecular biology research.The research direction of the laboratory focuses on the following aspects:
(1) Human genome research and research on the structure, function and expression of genes related to major diseases and important biological functions of cells;
(2) Research on gene expression regulation mechanism related to major diseases and important cell life activities;
The State Key Laboratory of Medical Molecular Biology of the Institute of Basic Medicine of the Chinese Academy of Medical Sciences is a comprehensive open laboratory in the field of medical research in China. This research group is an important part of the State Key Laboratory. Academician Liu Depei, the academic leader, and Academician Shen Yan, the research backbone, have been engaged in medical research together in this laboratory for nearly 20 years,After studying abroad and making great achievements in scientific research, Professor Zhu Dahai and Professor Zhang Xue joined the research group as distinguished professors to jointly carry out research work in important research directions of the laboratory.The researchers of this group have made important research results in the screening of disease genes and the regulation of eukaryotic gene expression. They have been rated as "outstanding contribution talents" at the national/provincial/ministerial level for many times, and have won many national/provincial/ministerial science and technology awards.He has made outstanding achievements in the function and pathogenesis of disease related genes, and has won the support of the National Science Fund for Distinguished Young Scholars.
With the development of molecular biology, especially genomics andProteomicsWith the further development of, various physical/chemical and biological new methods and technologies are constantly emerging and applied, generating and accumulating a large amount of genetic information.On the basis of existing work, this research group will further focus on outstanding talents and apply the combination of micro and macrosystems biologyIntegrating innovative thinking and high-tech platform, aiming at the key scientific problem of the function and expression regulation of important genes related to the occurrence/development of major diseases, and deeply exploring its internal mechanism.Through our efforts, we hope to make new breakthroughs in disease genomics research and apply the results of basic research to medicine, laying a theoretical foundation for gene diagnosis and treatment of major diseases.
Academic platform
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Proteomics aims to study the characteristics and functions of proteins, so as to comprehensively understand the growth process of normal and abnormal cells, the interaction between proteins and the regulation mechanism of protein level.High speed orUltrafast freezing centrifugeIt can effectively separate and purify proteins;Liquid chromatography can analyze and prepare samples;Rapid electrophoresis and two-dimensional electrophoresis are standard techniques for proteome separation;seniorGel imagerAfter electrophoresis, the separated proteins will be stained and imaged on the gel and further analyzed.
Core technology:HPLC is a classic instrument analysis method, but it has not been fully used in the field of nucleic acid analysis. The reason is that in many cases, nucleic acid analysis needs to be carried out under high temperature denaturation conditions (52-80 ℃), while the traditional HPLC separation system cannot solve the problem of high temperature resistance. The best Si matrix column can only withstand 60 ℃ at most, and its life is very short at this temperature,The unique DNASep column developed by American Transgenic Company is the core part of WAVE nucleotide fragment analysis system,DNASep column uses PS/DVB polymer microsphere as the stationary phase matrix and chemically bonded stationary phase C18. Thus, the column filler formed by PS/DVB and C18 has good thermal stability. It is the characteristics of high temperature resistance that ensure the accuracy and repeatability of its analysis results. At the same time, this separation column system is acid and alkali resistant, with long service life and low analysis cost.Because such polymer microspheres are small in size and have a large specific surface area, which ensures more interaction opportunities between nucleic acid fragments and stationary phase, the separation efficiency is high and the analysis time is short.
Instrument and equipment:AKTA explorer chromatography systems, WAVE denaturing high-performance liquid chromatography (DHPLC), micro purification liquid chromatography system, fast protein electrophoresis systemFull automatic gel imaging analysis system。
Academician of Research Institute
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Academician Liu Depei
Liu Depei, male academician, born on May 4, 1950.From 1978 to 1981, he studied for a master's degree in biochemistry at Hunan Medical College and obtainedMaster of MedicineFrom 1984 to 1986, he studied biochemistry and molecular biology at Peking Union Medical College and obtained a doctor's degree. After graduation, he stayed at the university to work.From 1987 to 1990University of California, San FranciscoConduct post doctoral research.He was promoted as a researcher in 1992, and was employed as a researcher in 1995China Union Medical UniversityDoctoral supervisor, elected academician of the Chinese Academy of Engineering in 1996.Currently, he is a researcher of Institute of Basic Medicine, Chinese Academy of Medical Sciences,School of Basic Medicine, Peking Union Medical UniversityProfessor, doctoral supervisor.
He has been engaged in the research of eukaryotic gene expression regulation and genetic gene therapy for a long time.So far, more than 100 papers have been published, and 64 papers have been included in SCI, with more than 300 citations.He won one first prize of the Ministry of Health for scientific and technological progress, one first prize of the Chinese Medical Science and Technology Progress Award, two second prizes, one second prize of Beijing Science and Technology Progress Award, and one fourth prize of the National Natural Science Award.In 1991, he was awarded the title of "Chinese Doctor Degree Winner with Outstanding Contributions", in 1993, he was awarded the title of "First Young and Middle aged Medical Science and Technology Star", in 1994, he was awarded the title of "National Young and Middle aged Expert with Outstanding Contributions", and in 1995, he was awarded the honorary title of "Outstanding Young Scholar".Supported by the National Natural Science Foundation of China for Outstanding Young and Middle aged Talents, the Science Fund for Outstanding Young Scholars, and the Cross Century Talent Fund of the National Family Education Commission.He has presided over and successfully completed a number of national key scientific research projects, including the National 863 Key Scientific Research ProjectsThalassemia geneTreatment (Z20-02-02), NSFC nuclear gene table sub projectGlobin geneResearch on temporal and spatial order of expression (9893320), National Natural Science Foundation for Distinguished Young Scholars (9525006), establishment of animal models of human diseases during the Ninth Five Year Plan (96-A23-06-02), and cooperation between mainland China and Hong Kong in developing a new method of modifying mouse genome (39910161991).
Academician Shen Yan (main research backbone)
Shen Yan, male, academician, born in October 1951.Won in 1989China Union Medical UniversityHe holds a master's degree in biochemistry and is currently a researcher of the Institute of Basic Medicine of the Chinese Academy of Medical Sciences,National Human Genome North Research CenterExecutive Deputy Director.Elected in 2003Academician of CAS。Served as the deputy leader of the 863 Expert Group on Gene Operation in Biology and Modern Agricultural Technology, a member of the Discipline Review Group of the Academic Degrees Committee of the State CouncilNational Science and Technology AwardMember of the evaluation committee and member of the evaluation committee for senior professional and technical qualifications of the Ministry of Health.
Professor Zhu Dahai (main research backbone)
Zhu Dahai, male, professor, born in 1956, obtained a doctor's degree in molecular genetics from North Carolina State University, did postdoctoral research at Howard Hughes Medical Institute of Duke University School of Medicine, and served as an assistant researcher in the growth and developmental biology laboratory of the National Institutes of Health (NIH),From May 1998 to December 1998, he served as assistant research professor of North Carolina State University in the United States, and from January 1999 to January 2003, he served as professor and doctoral supervisor of the Department of Life Sciences of Harbin Institute of Technology;Since January 2003, he has been a distinguished professor of the Chinese Academy of Medical Sciences and Peking Union Medical University.He has served as a member of the Science Department of the Science and Technology Commission of the Ministry of Education, a member of the second evaluation committee of the National Natural Science Foundation of China, a member of the 863 expert group on biotechnology, a standing director of the Chinese Society of Genetics, a chairman of the Animal Genetics Professional Committee, a standing director of the Chinese Society of Cell, and a vice chairman of the Professional Committee of Stem Cell, Cell Differentiation and Developmental BiologyEditorial board member of Journal of Translational Medicine and other magazines.
Professor Zhang Xue (main research backbone)
Zhang Xue, male, professor, was born in July 1964.In 1986, he graduated from the Medical Department of China Medical University with a bachelor's degree;Graduated from China Medical University in 1994Cell Biology, received a doctor's degree.From 1992 to 1993, he studied in the Japanese National Cancer Center Research Institute. From 1996 to 1998, he successively worked as a postdoctoral fellow in the University of Pennsylvania Medical School and Harvard Medical School/Massachusetts General Hospital Cancer Center.Since 1994, he has served as professor of the Department of Genetics of the School of Basic Medicine of China Medical University, director of the Key Laboratory of Cell Biology of the Ministry of Health from 1998 to 2002, distinguished professor of China Union Medical University, Chinese Academy of Medical Sciences, and director of the Department of Genetics of the School of Basic Medicine of the Institute of Basic Medicine.
