In order to carry out academic exchanges and cooperative research at home and abroad in the field of molecular biology and obtain high-level achievements and talents, the National Planning Commission and the Chinese Academy of Sciences organized an expert group in 1984 to demonstrate and decided to establish a national key laboratory of molecular biology in the Institute of Biochemistry.After preparation, the laboratory passed the acceptance in 1986 and was officially opened to the public in 1987.This is the first key laboratory set up by the state in the field of life science research.Over the past 20 years, the laboratory has gone through six sessions, with Zhang Youshang, Ao Shizhou, Lin Qiwho, Jin Youxin and Li Lin as the laboratory directors of each session;Zhang Youshang, Lin Qihe, Ao Shizhou, Liao Kan, Wang Nduo and Shi Yunyu served as the directors of the academic committees of each session.At present, it has entered the seventh session. The laboratory director is researcher Zhou Jinqiu, and the academic committee director is academician Xu Guoliang.[1]
Positioning and research direction
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The National Key Laboratory of Molecular Biology is positioned as an innovative basic research laboratory, aiming to become the international forefront in the field of molecular biology, solve major scientific problems in the field of molecular biology, reveal the essence and laws of life phenomena, and provide theoretical basis for the prevention and treatment of major diseases.The laboratory takes "gene function and its regulation" as the research core, uses molecular biology, biochemistry and structural biology research methods, and combines research systems in cell biology and other related fields to deploy three research directions: (1) gene expression and epigenetic regulation;(2) RNA metabolism, function and regulation;(3) Signal transduction network protein function and regulation.
Academic Committee
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Director: Academician Xu Guoliang (Center for Excellence and Innovation in Molecular Cell Science, Chinese Academy of Sciences)
Member: Academician Li Peng (School of Life Sciences, Tsinghua University)
Academician Shao Feng (Beijing Institute of Life Sciences)
Academician Wang Endo (Center for Excellence and Innovation in Molecular Cell Science, Chinese Academy of Sciences)
Academician Zhang Mingjie (Department of Life Sciences, Hong Kong University of Science and Technology)
Academician Song Baoliang (School of Life Sciences, Wuhan University)
Professor Tang Qiqun (Shanghai Medical College, Fudan University)
Researcher Wang Zefeng (Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences)
Researcher Xu Ruiming (Institute of Biophysics, Chinese Academy of Sciences)
Professor Xu Yanhui (School of Basic Medicine, Fudan University)
Researcher Yang Yungui (Beijing Institute of Genomics, Chinese Academy of Sciences)
Professor Zhou Binbing (School of Medicine, Shanghai Jiaotong University)
Researcher Zhou Jinqiu (Center for Excellence and Innovation in Molecular Cell Science, Chinese Academy of Sciences)
Scientific research team
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"Gene expression and epigenetic regulation" team
Research team leader of histone modification and its function: Chen Degui, doctoral supervisor, chief scientist of major research projects of the Ministry of Science and Technology
Research leader of gene expression regulation of morphogenesis: Chen Jiangye, doctoral supervisor, winner of National Science Fund for Distinguished Young Scholars
Research team leader of structural biology research on epigenetic regulation: doctoral supervisor Chen Yong.
Research leader of structural biology of chromatin modified protein: Ding Jianping, doctoral supervisor, winner of National Science Fund for Distinguished Young Scholars, and chief scientist of major scientific research program of the Ministry of Science and Technology
Research leader of gene expression regulation and functional genomics: Liu Xin, doctoral supervisor
Research team leader of immune system diversification: Meng Feilong, doctoral supervisor.
Team leader of the research on spermatogonial stem cell fate determination and meiosis initiation: Tong Minghan, doctoral supervisor.
Research leader of DNA methylation and development regulation: Xu Guoliang, doctoral supervisor, winner of National Science Fund for Distinguished Young Scholars, and chief scientist of 973 Program
Leader of telomere and cell aging research team: Zhou Jinqiu, doctoral supervisor, winner of National Science Fund for Distinguished Young Scholars, and leader of outstanding innovation group
"RNA metabolism, function and regulation" team
The function of long non coding RNA and its role in determining the fate of stem cells Research leader: Chen Lingling, doctoral supervisor, winner of the National Science Fund for Distinguished Young Scholars
Research leader of regulation and function of RNA nucleocytoplasmic transport: Cheng Hong, doctoral supervisor
Research team leader of regulation and function of mammalian cell mRNA splicing: Hui Jingyi, doctoral supervisor
Research leader of functional mechanism of non coding RNA in tumorigenesis and spermatogenesis: Liu Mofang, doctoral supervisor, winner of National Science Fund for Distinguished Young Scholars, and chief scientist of key research and development program of the Ministry of Science and Technology
DNA damage repair;RNA metabolism;Single molecule fluorescence imaging research team leader: Liu Jiaquan doctoral supervisor
Research team leader for quality control of protein biosynthesis: Wang Endo, doctoral supervisor, academician of the Chinese Academy of Sciences, and academician of the Third World Academy of Sciences
Research leader of molecular mechanism of small molecule RNA regulating gene expression: Wu Ligang, doctoral supervisor
Research leader of RNA mediated gene expression regulation molecular mechanism: Yang Hui, doctoral supervisor
Research leader of molecular basis of protein biosynthesis and related diseases: Zhou Xiaolong, doctoral supervisor
"Signal transduction network protein function and regulation" team
Ultra low temperature electron microscope research on protein folding and degradation machine Research team leader: Cong Yao, doctoral supervisor
Leader of structural biology research on cell surface receptors and cell interactions: He Yongning, doctoral supervisor
Research leader of protein folding and interaction: Hu Hongyu, doctoral supervisor
Research leader of protein degradation and molecular recognition: Hu Ronggui, doctoral supervisor, winner of National Science Fund for Distinguished Young Scholars
Research team leader of biochemical cell mechanism of natural immunity and inflammation and related diseases: Hou Fajian, doctoral supervisor.
Research leader of protein interaction network of cell signal: Li Lin, doctoral supervisor, academician of Chinese Academy of Sciences, president of Shanghai Institute of Life Sciences, Chinese Academy of Sciences, chief scientist of major scientific research program of the Ministry of Science and Technology, winner of National Science Fund for Distinguished Young Scholars
Research team leader of membrane protein structure and function and cutting-edge technology: Li Fan, doctoral supervisor, and candidate of Shanghai "Pujiang Talent Plan Class A"
Research team leader: Ouyang Bo doctoral supervisor
Research team leader of membrane protein function and structure pharmacology: Wang Sheng, doctoral supervisor
Research leader of regulation of biomembrane on immune receptor function: Xu Chenqi, doctoral supervisor, winner of National Science Fund for Distinguished Young Scholars.
Distinguished research consultant
Research leader of the regulation of symbiotic nitrogen fixation and nodulation genes: Hong Guofan, doctoral supervisor, academician of the Chinese Academy of Sciences, and academician of the Third World Academy of Sciences
Research team leader of molecular basis of sperm maturation in epididymis: Zhang Yonglian, doctoral supervisor, academician of Chinese Academy of Sciences
Research leader of gene expression regulation of cholesterol metabolism balance: Li Boliang, doctoral supervisor, chief scientist of major scientific research program of the Ministry of Science and Technology, and winner of National Science Fund for Distinguished Young Scholars
Platform construction
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(1) Molecular Biology Technology Platform (2) Chemical Biology Technology Platform
