Sulfoxide chloride, also known as thionyl chloride, is ainorganic compound, chemical formula is SOCltwo, colorless or yellow odorous liquid, with strong pungent smell, can be mixed with benzenechloroform、carbon tetrachlorideIt is miscible with other solvents, hydrolyzed in water, and decomposed by heating. It is mainly used to manufacture acyl chloride, and also used in the production of pesticides, medicines, dyes, etc.
Appearance: colorless to light yellow liquid with strong pungent smell
Sulfuroyl chloride after distillation purification
Solubility: miscible in benzene, chloroform, carbon tetrachloride and other solvents
chemical property
Capable of dissolving certain metalsIodide, decomposed into sulfur dioxide andHydrogen chloride：
SOCltwo+ HtwoO = SOtwo+ 2HCl
Heating to 140 ℃ and starting to decompose to generate chlorinesulfur dioxideandSulfur monochloride。[1]Generated by reaction with sulfonic acidSulfonyl chlorideAnd react with Grignard reagent to generate corresponding sulfoxide compound.Hydroxylatedphenol, alcohols and organic compounds react to produce corresponding chlorides. Its chlorine atom has a remarkable ability to replace the hydroxyl sulfhydryl group, and sometimes it can also replace sulfur dioxide, hydrogen and oxygen.
Preparation method
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Industrial production methods of thionyl chloride mainly include chlorosulfonic acid method, sulfur dioxide gas phase method andPhosphorus oxychlorideThere are three co production methods.[2]
application area
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Mainly used for manufacturingAcyl chloridechemical compound,Sulfoxide chloride is widely used because of its mild reaction conditions, good purity and high yield[2]。It is also used in the production of pesticides, medicines, dyes, etc.
Molecular structure data
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Molar refractive index: 20.60
Molar volume (cmthree/mol）：60.8
Isotonic specific volume (90.2K): 179.9
Surface tension (dyne/cm): 76.7
Polarization (10-24cmthree）：8.17
Calculate chemical data
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Reference value for drainage parameter calculation (XlogP): 1.5
Number of hydrogen bond donors: 0
Number of hydrogen bond receptors: 1
Number of rotatable chemical bonds: 0
Number of tautomers: 0
Topological molecule polar surface area (TPSA): 17.1
Number of heavy atoms: 4
Surface charge: 0
Complexity: 29
Number of isotope atoms: 0
Determine the number of atomic structure centers: 0
Number of uncertain atomic structure centers: 0
Determine the number of chemical bond structure centers: 0
Number of uncertain chemical bond structure centers: 0
Number of covalent bond units: 1
toxicology data
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1. Toxic, its vapor irritates eyes and mucous membranes, and liquid touching skin can cause burns.
2. The toxicity is greater than that of sulfur dioxide, and the vapor has obvious irritation on the respiratory tract and conjunctiva.Burns caused by skin contact.Maximum allowable concentration in workplace 24.15mg/mthree(in air).Cat Inhalation 85mg/mthreeConcentration of steam can cause death in 20 minutes.
3. Acute toxicity LCfifty：2435mg/mthree(Inhaled by rats).
First aid measures
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Skin contact: Take off contaminated clothes immediately, and wash with plenty of flowing water for at least 15 minutes.Get medical attention.
Eye contact: immediately lift the eyelid, and thoroughly flush it with a large amount of flowing water or physiological saline for at least 15 minutes.Get medical attention.
Inhalation: quickly leave the site to a place with fresh air.Keep the respiratory tract unobstructed.If breathing is difficult, give oxygen.If breathing stops, perform artificial respiration immediately.Get medical attention.
Ingestion: Rinse with water and drink milk or egg white.Get medical attention.
Fire fighting measures
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Hazard characteristics: the product is incombustible, and will decompose and release irritating toxic smoke such as sulfur dioxide and hydrogen chloride when encountering water or moisture.Thermal decomposition can also produce toxic substances.It is corrosive to many metals, especially in the presence of humid air.
Extinguishing method: firefighters must wear acid and alkali resistant fire-fighting clothes.
Extinguishing agent: carbon dioxide, sand.Do not use water.
Leakage emergency treatment
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Evacuate the personnel in the leakage contaminated area to a safe area quickly, isolate them, and strictly restrict access.It is recommended that emergency treatment personnel wear self-contained positive pressure respirators and acid and alkali resistant work clothes.Enter the site from the upwind.Cut off the leakage source as much as possible.
Small amount of leakage: absorb or absorb with sand or other incombustible materials.
Large amount of leakage: build a dike or dig a pit to receive.Remove under the guidance of experts.
Handling storage
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Operation precautions: closed operation, local exhaust.Operators must be specially trained and strictly abide by the operating procedures.It is recommended that operators wear self-priming filter type gas mask (full mask), rubber acid and alkali resistant clothing, and rubber acid and alkali resistant gloves.Prevent vapor leakage into the air of the workplace.Avoid contact with alkalis.In particular, avoid contact with water.Load and unload gently during transportation to prevent damage to packaging and containers.Provide leakage emergency treatment equipment.Empty containers may leave harmful substances.
Precautions for storage: store in a cool and ventilated warehouse.The storage temperature shall not exceed 25 ℃,relative humidityNot more than 75%.Keep container sealed.It shall be stored separately from alkalis, etc., and mixed storage is strictly prohibited.The storage area shall be equipped with leakage emergency treatment equipment and appropriate materials.
security information
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Safety terminology
S26：In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
After eye contact, immediately flush with plenty of water and seek medical advice.
S27：Take off immediately all contaminated clothing.
Take off all contaminated clothes immediately.
S28：After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer).
After skin contact, immediately use a large amount of(designated by the manufacturer).
S36/37/39：Wear suitable protective clothing, gloves and eye/face protection.
Wear appropriate protective clothing, gloves and eye/face protection.
S45：In case of accident or if you feel unwell, seek medical advice immediately (show the lable where possible).
In case of an accident or feeling unwell, seek medical advice immediately (show the label if possible).
