Azopropyl ring, also known as ethylene imine and aziridine, is an organic compound with the chemical formula CtwoHfiveN，It is highly toxic[1]It is mainly used to manufacture drugs such as reactive dyes and anticancer agents, change the properties of synthetic fibers and process paper, etc. It is also used as a raw material for organic synthesis.
On October 27, 2017, the list of carcinogens published by the International Agency for Research on Cancer of the World Health Organization (WHO) was preliminarily sorted out for reference, and aziridine was included in the list of Class 2B carcinogens.[2]
It is mainly used to manufacture drugs such as reactive dyes and anticancer agents, change the properties of synthetic fibers, process paper, etc., and also as a raw material for organic synthesis.
Health hazard: This product is strongly irritant and corrosive, stimulates the central nervous system, can cause kidney damage, and has sensitization effect.
Acute poisoning: the main manifestations are severe irritation of eyes, mouth and respiratory tract, conjunctiva, keratitis, runny nose, and laryngeal edema;Severe cases may have diphtheria like changes and pulmonary edema.May cause kidney damage.Splash into eyes may cause burns.Skin contact with liquid may cause burns;This product is allergic and can cause allergic dermatitis.
Toxicological data and environmental behavior
Toxicity: It is highly toxic.
Acute toxicity: LDfifty: 15mg/kg (rat by mouth);17mg/kg (guinea pig percutaneous);LCfifty：450mg/mthree, half an hour (inhaled by rats);1790mg/mthree, half an hour (inhaled by mice);Human inhalation 180mg/mthreeIt has obvious irritation effect on eyes and nose;Human oral lethal dose is 5mg/kg.
Subacute and chronic toxicity: 0.42~0.83mg/kg × 5~30 times by mouth in rabbits, causing kidney damage and increased NPN in blood.
Carcinogenicity test showed positive reaction in animals.
Hazard characteristics: Its vapor and air form an explosive mixture, which can cause combustion and explosion when encountering open fire and high heat.It can react strongly with oxidants.It can react violently with nitric acid, sulfuric acid, hydrochloric acid, acetic acid, chlorosulfonic acid, chlorine, carbon disulfide, sodium hypochlorite, etc.Its vapor is heavier than air, and can spread to a relatively far place at a lower place. It will ignite when encountering open fire.
Maximum allowable concentration of hazardous substances in the air of workplace
0.02mg/mthree
Former Soviet Union
Maximum allowable concentration of harmful substances in the atmosphere of residential areas
0.001mg/mthree(Maximum value, day and night mean value)
Olfactory threshold concentration
3.5mg/mthree
Emergency Management
Announce
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Leakage emergency treatment
Evacuate the personnel in the leakage pollution area to the safety area, prohibit irrelevant personnel from entering the pollution area, and cut off the fire source.Emergency personnel shall wear positive pressure self-contained breathing apparatus and chemical protective clothing.Do not contact the leakage directly, wash with a large amount of water, and put the diluted washing solution into the waste water system.In case of a large amount of leakage, the dike shall be used to collect it, and then it shall be collected, transferred, recycled or discarded after harmless treatment.
Protective measures
Respiratory system protection: gas mask should be worn when contacting with its vapor.In case of emergency rescue or evacuation, it is recommended to wear self-contained breathing apparatus.
Eye protection: wear chemical safety goggles.
Protective clothing: wear anti-corrosion work clothes.
Hand protection: wear chemical resistant gloves.
Others: Smoking, eating and drinking are prohibited at the work site.After work, take a shower and change clothes.Regular physical examination.
First aid measures
Skin contact: Take off the contaminated clothes, and immediately flush thoroughly with a large amount of flowing water for at least 15 minutes.Get medical attention.
Eye contact: immediately open the upper and lower eyelids and flush with flowing water or physiological saline for at least 15 minutes.Get medical attention.
Inhalation: quickly leave the site to a place with fresh air.Keep the respiratory tract unobstructed.Give oxygen when breathing is difficult.When breathing stops, perform artificial respiration immediately.Get medical attention.
Ingestion: Rinse the mouth and give milk or egg white to those who take it by mistake.Get medical attention.
security information
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Safety terminology
S45：In case of accident or if you feel unwell, seek medical advice immediately (show the lable where possible).
In case of an accident or feeling unwell, seek medical advice immediately (show the label if possible).
S53：Avoid exposure - obtain special instructions before use.
Avoid contact and obtain special instructions before use.
S61：Avoid release to the environment. Refer to special instructions/Safety data sheets.
Avoid releasing into the environment, refer to special instructions/safety receipt instructions.
Risk terminology
R11：Highly flammable.
Highly flammable.
R26/27/28：Very toxic by inhalation, in contact with skin and if swallowed.
Very toxic by inhalation, in contact with skin, and if swallowed.
R34：Causes burns.
Causes burns.
R45：May cause cancer.
May cause cancer.
R46：May cause heritable genetic damage.
It may cause irreversible genetic damage.
R51/53：Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
It is toxic to aquatic organisms and may cause long-term adverse effects in the aquatic environment.
