Neutrophils

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This entry is made by Baidu Health Medical Code - Neutrophil Provide content.
Neutrophil is a common measurement in blood test, and its abnormality can reveal Acute infection trauma Rheumatic disease Aplastic anemia And other diseases. It is worth noting that radioactive substances, chemical poisons and some drugs may also cause abnormalities of neutrophils.
Neutrophil levels above or below the normal range are considered abnormal. This can be a symptom of a disease or a reflection of a physiological state, such as gestation childbirth The physiological increase of neutrophils may also be caused by intense exercise, full meals, showers, high temperature or severe cold. If the subject does not truthfully inform the doctor of such situation when receiving the examination, the doctor may not accurately judge the cause of neutrophil abnormalities.
The diagnosis and treatment of the disease depends on the patient's specific condition. If neutrophils are elevated, especially in patients with fever Chest pain abdominal pain It is very important to see a doctor for symptoms such as fever, cough and fatigue, or neutropenia. Neutropenia, accompanied by fever, cough, exertion and other symptoms should be treated in time.
TCM disease name
Neutrophils
Foreign name
Neutrophil
Visiting department
blood specialty
Multiple population
All groups
Common diseases
blood
common symptom
Fever abdominal pain , cough Muscle soreness , dizziness, bleeding
atlas

Science popularization in China

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The certification expert of this term is

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Yang Tiesheng | Chief physician

Laboratory Department of Peking University People's Hospital compose

essential information

TCM disease name
Neutrophils
Foreign name
Neutrophil
Visiting department
blood specialty
Multiple population
All groups
Common location
blood
common symptom
Fever abdominal pain , cough Muscle soreness , dizziness, bleeding

Normal reference value

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Normal value

Neutrophils mainly include the ratio of neutrophils and the absolute value of neutrophils.
The normal value of neutrophil ratio varies among different populations
  • Adult: 50%~70%.
  • Newborns and infants: 31%~40%.
  • Children: 50%~70%.
The absolute value of neutrophils in different populations and the normal value are also different
  • Adult: (1.5~8.0) × 10 ^ 9/L.
  • Newborn: (6.0~26.0) × 10 ^ 9/L.
  • 28 days~<6 months: (0.6~7.5) × 10 ^ 9/L 6 months~<1 year: (0.8~6.4) × 10 ^ 9/L
  • 1~<2 years old: (0.8~5.8) × 10 ^ 9/L
  • 2~<6 years old: (1.2~7.0) × 10 ^ 9/L
  • 6~<13 years old: (1.6~7.8) × 10 ^ 9/L
  • 13~18 years old: (1.8~8.3) × 10 ^ 9/L
It should be noted that the reference values of test sheets issued by different medical institutions may be different in real life due to different instrument precision, different laboratories and other factors.

Abnormal indicators

The abnormal neutrophil is defined as the level of neutrophil exceeds or falls below the normal range.

Result error

gestation childbirth Strenuous exercise Postnatal, full meal, shower, high temperature or severe cold may also cause physiological increase of neutrophils. If the subject does not truthfully inform the doctor of such situation when receiving the examination, the doctor may not accurately judge the cause of neutrophil abnormalities.

Indicator interpretation

The neutrophil is decreased, indicating that the subject may suffer from infection, aplastic anemia and other diseases. In addition, radioactive substances, chemical poisons and certain drugs may also cause neutropenia.
The neutrophil is elevated, indicating that the subject may have Acute infection trauma gout Rheumatoid arthritis And so on. In addition, pregnancy, childbirth, after strenuous exercise, full meal, shower, high temperature or severe cold may also cause physiological increase of neutrophils.
If neutrophils are combined with blood routine test, blood biochemistry, bone marrow biopsy and other auxiliary examinations, it has high diagnostic value for acute infection, aplastic anemia and other diseases.

Index identification

Neutrophils are not easily confused with other indicators.

High indicators

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The increase of neutrophils indicates that the subject may have acute infection, trauma, gout, rheumatoid arthritis, etc. In addition, pregnancy, childbirth, after strenuous exercise, full meal, shower, high temperature or severe cold may also cause physiological increase of neutrophils.

Reasons for high

Both disease and non disease factors can cause neutrophil elevation. The common disease factors are acute infection, trauma, gout, rheumatoid arthritis, etc. The common non disease factors are pregnancy, childbirth, after strenuous exercise, full meal, shower, high temperature or cold and other physiological factors may also cause neutrophil elevation.
  • Disease factors
Acute infection: Neutrophils have anti-inflammatory, bactericidal, phagocytic and other effects, and are an important part of human immunity. Therefore, acute infection, especially caused by Staphylococcus aureus, hemolytic streptococci and Streptococcus pneumoniae, is the most common cause of neutrophil elevation. Common infectious diseases include Acute pneumonia Acute enteritis acute cholecystitis Acute cystitis and Acute pyelonephritis Etc.
Trauma: Severe tissue damage usually causes inflammatory reaction in the human body. Neutrophils may rise 12~36 hours after inflammation.
Rheumatic diseases: gout Rheumatoid arthritis Rheumatic diseases may also lead to the increase of neutrophils.
  • Non disease factors
Late pregnancy Physiological factors such as childbirth, strenuous exercise, satiety, shower, high temperature or severe cold may also lead to the temporary increase of neutrophils, but it has no special clinical significance.
It should be noted that the test results reported by different medical institutions in real life may be different due to different instrument precision, different laboratories and other factors. The specific diagnosis should be subject to the doctor.

Indication for medical treatment

Neutrophil elevation is usually associated with acute infection, trauma, rheumatic disease and other factors. Therefore, if neutrophils are found to be elevated during examination, especially patients with fever, chest pain, abdominal pain, trauma, vomiting, diarrhea, arthralgia and even coma, they should go to the hospital in time.

inspect

High neutrophils usually indicate that patients may suffer from acute infection, trauma, rheumatic diseases and other diseases. Different diseases require different further examinations.
  • Acute infection : The doctor will first conduct C-reactive protein, erythrocyte sedimentation rate and other tests to initially determine whether the patient has infection or inflammatory reaction; Secondly, doctors will collect blood, pus and other samples of patients for bacterial culture according to the situation, so as to clearly diagnose and judge the pathogen.
  • trauma : The doctor will initially judge whether the patient has body surface trauma through physical examination; Secondly, doctors will pass X-ray examination , CT or MRI Scan to determine whether the patient has tissue and organ trauma, and judge the severity of the trauma.
  • Rheumatic disease : First, the doctor will pass the C-reactive protein Erythrocyte sedimentation rate And blood biochemical tests to determine whether the patient has inflammatory reaction and metabolic disorder; Secondly, doctors will determine whether the patient has rheumatic disease through immunological tests such as anti nuclear antibody and rheumatoid factor.

Treatment mode

If it is found that the neutrophil is on the high side, it needs to be treated according to the cause to correct the high neutrophil. Different diseases have different treatment methods.
  • Physiological neutrophil elevation: usually without special clinical significance, no treatment is needed.
  • Acute infection: For patients with acute infection, doctors will first determine the location of infection and the type of bacteria, and then select specific antibiotics for treatment according to the corresponding location and type of bacteria. Common antibiotics include penicillin, cephalosporins, macrolides, etc. If the antibiotic treatment fails, the doctor will also decide whether to remove the infected focus and drain it through surgery according to the patient's condition.
  • Trauma: for the neutrophil elevation caused by trauma, the doctor will treat the wound with a combination of drug treatment and surgical treatment to treat and prevent infection when the injury site and severity are clear.
  • Rheumatic disease: For patients with rheumatic disease, doctors will first control the condition through drug treatment. Common drugs include NSAIDs methotrexate Glucocorticoid Colchicine and Allopurinol For patients with serious illness, doctors may choose surgical treatment at their discretion.

Dietary guidance

  • Diet recommendation: Patients with elevated neutrophils should eat a light diet and eat more fresh vegetables and fruits, soy products, eggs, milk and various cereal products.
  • Diet taboo: It varies according to the diseases that cause neutrophil elevation. For example, patients with gout should eat less foods with high purine content, such as Animal viscera , pork, beef, mutton, seafood, etc. Avoid excessive spicy and stimulating food and sweets.

Daily attention

Patients with high neutrophils need to pay attention to the following aspects in their daily life:
  • Lifestyle: Quit smoking and drinking, work and rest regularly, avoid staying up late and overwork, ensure adequate sleep, and adjust your attitude in time. Patients after surgery should take medicine according to the doctor's advice and take regular reexamination.
  • Exercise: Take proper exercise to strengthen the physique and improve the immunity of the body, but pay attention to taking protective measures during exercise, such as wearing knee pads, wrist pads, elbow pads, etc.

Curative

  • High neutrophils can be cured.
  • After a clear diagnosis, doctors will take appropriate treatment measures. After active and regular treatment, most patients' neutrophils will return to normal. Most patients do not need reexamination after recovery, but some patients may need reexamination due to serious illness, and it is recommended to follow the doctor's advice.

Indicators are low

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The neutrophil is decreased, indicating that the subject may suffer from infection, aplastic anemia and other diseases. In addition, radioactive substances, chemical poisons and certain drugs may also cause neutropenia.

Reasons for low

The cause of low neutrophils may be related to infection, aplastic anemia and other disease factors. In addition, non disease factors such as radioactive substances, chemical poisons and certain drugs may also lead to neutropenia.
  • Disease factors
Infection: When typhoid bacillus and paratyphoid bacillus are infected, the monocyte macrophage system of the patient is abnormal, so the neutrophils of the patient may be relatively reduced. In addition, since virus and parasite infections mainly cause abnormalities of lymphocytes and eosinophils, some viral and parasite infections may also lead to a decrease in the percentage of neutrophils in neutrophil related tests, such as influenza, viral hepatitis, chicken pox, malaria, and kala azar.
Aplastic anemia: Aplastic anemia is a kind of bone marrow hematopoietic failure. Patients usually show pancytopenia, so neutrophils will also decrease.
  • Non disease factors
Physical and chemical factors damage: physical factors such as X ray, γ ray, radionuclide and chemical substances such as benzene, lead, mercury may damage the hematopoietic system, resulting in neutropenia.
Drugs: Chloramphenicol, sulfonamides, paclitaxel, docetaxel, vincristine and other drugs may also damage the hematopoietic system, leading to neutropenia.
It should be noted that due to the complexity of the human body, patients with abnormal neutrophils should mainly refer to the opinions of the doctor in charge.

Indication for medical treatment

Neutropenia is usually associated with infection, aplastic anemia, exposure to radioactive substances, chemical poisons and other factors. Therefore, for neutropenia, especially with fever cough weak Muscle soreness rash Patients with dizziness, bleeding and other symptoms should go to the hospital in time.

inspect

If neutrophils are found to be low, it is mainly related to infection, aplastic anemia and other disease factors. Different diseases require different further examinations:
  • Infection: if suspected bacterial infection The doctor will first conduct a wida test to preliminarily determine whether the patient is infected with salmonella typhi; Secondly, doctors will collect blood, pus, feces, urine and other samples of patients for bacterial culture according to the situation, so as to make a clear diagnosis and determine the pathogen. If virus infection is suspected, doctors will first make early diagnosis through virus PCR test, and then further confirm the diagnosis through virus isolation and serum immunology test.
  • Aplastic anemia : If the patient is suspected to have aplastic anemia, the doctor will make a clear diagnosis through bone marrow biopsy, and find the possible cause of the disease through immunological examination.

Treatment mode

If the neutrophil is found to be low, it needs to be treated according to the cause to correct the low neutrophil. Different diseases have different treatment methods:
  • Infection: doctors will select appropriate drugs for symptomatic, antibacterial or antiviral treatment on the basis of identifying the infection site and pathogen. Common drugs include antipyretic and analgesic drugs, ribavirin, oseltamivir, lamivudine, ofloxacin, cephalosporin, etc.
  • Aplastic anemia: First, doctors will take symptomatic treatment measures such as blood transfusion, hemostasis and infection control to control the patient's condition; Secondly, doctors will use anti lymphocyte/thymocyte globulin, cyclosporine, androgen, hematopoietic growth factor and other drugs to try to treat the cause to alleviate the condition. In addition, if the conditions are met, but the above treatment effect is not good, the doctor will recommend to accept hematopoietic stem cell transplantation.
  • Physical and chemical factors injury: First, the doctor will let the patient immediately get rid of physical and chemical poisons, and protect the injured part of the patient. Secondly, doctors will control inflammatory reaction and prevent infection through drug treatment as appropriate, and surgery may be required when necessary.
  • Drug effect: If neutropenia is related to the drug, the doctor will ask the patient to stop or change the medicine to reduce the side effects of the drug.

Dietary guidance

  • Diet recommendation: Patients with low neutrophils should appropriately eat more food rich in trace elements and high-quality protein, such as fresh vegetables and fruits, fish, chicken, milk and eggs.
  • Diet taboo: patients with low neutrophils should eat less spicy and stimulating food, such as pepper, garlic, onion, etc.

Daily attention

Patients with low neutrophils need to pay attention to the following aspects in their daily life.
  • Lifestyle: quit smoking and drinking, work and rest regularly, avoid staying up late and overwork, ensure adequate sleep, and adjust your mind in time.
  • Exercise: Take proper exercise to strengthen the body, improve the immunity of the body, take protective measures during exercise, and avoid dangerous exercise.
  • Others: pay attention to personal hygiene, wash hands and disinfect frequently, and pay attention to the hygiene of drinking water.

Curative

Some patients with low neutrophils can be cured. After a clear diagnosis, doctors will take appropriate treatment measures. After active and regular treatment, most patients' neutrophils will return to normal.
After the neutrophils return to normal, patients also need to go to the hospital regularly to review neutrophils under the guidance of doctors, especially patients with aplastic anemia and other blood system diseases, so that doctors can monitor the efficacy and adjust the treatment plan in time.

scientific research

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July 2022, published on American Chemical Society In a new study on its journal ACS Central Science Institute of Nanophotonics, Jinan University The research team led by Professor Li Baojun and Professor Zheng Xianchuang immunity And intelligent optical manipulation Organic combination , realizing the use of light to turn neutrophils into "micro robots" for disease treatment in vivo.
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