Nitric oxide synthase

Chemical terminology

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nitric oxide Synthase (NOS) is a isozyme , respectively in endothelial cells 、 macrophage , Nerve Phagocyte and nerve cell Medium. Nitric oxide synthase exists in neuron In, in different Brain region present Selective distribution 。 Because nitric oxide is very unstable, it seems easier to study the enzymes that produce nitric oxide, especially nitric oxide synthase Antagonist The discovery of nitric oxide has greatly promoted the research on the function of nitric oxide.

Chinese name: Nitric oxide synthase
Extract: Sharp sea dragon, oyster, protamine

Features: Assist cell communication and unite with primordial membrane
Protection: Nitric oxide has neuroprotective effect

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nitric oxide Synthases belong to nervous system , which Isoenzyme There are three subtypes, namely Normal state Hypoexpressive neuron Type I nitric oxide synthase (nNOS) and Endothelial nitric oxide synthase (eNOS) and in After injury Induced expression of inducible nitric oxide synthase (iNOS). originate Inducible nitric oxide synthase And neuronal nitric oxide synthase Toxic effect , from endothelium The nitric oxide of type I nitric oxide synthase has neuroprotective effect. Among them marine organism As an enzyme extracted from the main raw material, it is an endothelial nitric oxide synthase. Academic name:“ Nitric oxide marine synthase " (NOSS), this enzyme has a higher activity, which can enhance the role of nitric oxide circulation mechanism in the body and continuously produce nitric oxide. However, this enzyme is rare and must be made of marine organisms Jianhailong 、 Oysters 、 Protamine Only when rare marine species are extracted can they be produced.

Substance classification

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NNOS (NOS1) and eNOS (NOS3) are calcium dependent, and iNOS (NOS2) is calcium independent. NNOS also exists in Myocardial tissue in

NO S to L-Arginine As substrate, NO and L are generated by oxygen- Citrulline 。 NOS can also be generated Oxidation product

Neurotype nitric oxide synthase (abbreviated as nNOS or NOS1)

to central nervous system and Peripheral nervous system Of Nervous tissue Internally generated nitric oxide , and assist Cellular communication And combined with the original membrane.

Inducible nitric oxide synthase (iNOS or NOS2)

Nitric oxide utilizing oxidative stress （ Free radical ）, assist macrophage stay immune system Middle confrontation pathogen 。 It also exists in cardiovascular system Inside. Different from constructive nitric oxide synthase, it only functions after cells are stimulated and activated, and produces more nitric oxide.

Endothelial nitric oxide synthase (eNOS or NOS3)

It produces nitric oxide in blood vessels and helps regulate vascular function. It is associated with cells surrounded by primary membrane and with high basal body membrane in cells.

catalytic reaction

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nitric oxide Synthase catalyzes the following reactions:

L-arginine + 3/2 NADPH + H + 2 O 2= citrulline + nitric oxide + 3/2 NADP

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