γ - glutamyltransferase (γ - GT) is widely distributed in human tissues, most of which is in the kidney, followed by the pancreas and liver, and most of which is in the liver during the embryonic stage.In the liver, γ - GT is mainly distributed in the cytoplasm of hepatocytes and the epithelium of intrahepatic bile ducts, and γ - GT in normal human serum is mainly from the liver.Alcoholism or long-term acceptance of certain drugs, such as phenobarbital, phenytoin sodium, antipyrine, etc., increased serum γ - GT activity;Oral contraceptives can also increase the results of γ - GT determination.Clinically, this enzyme is mainly used to diagnose hepatobiliary diseases, and is an indicator of biliary obstruction and hepatitis activity.
Chinese name
Gamma glutamyl transpeptidase
Foreign name
γ-glutamyl transpeptidase
science
biology
stroma
glutathione
atlas
Science popularization in China
Committed to authoritative science communication
The certification expert of this term is
Zhang Jingbo|researcher
Institute of Basic Medicine, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical Collegeto examine
1. γ - glutamyltranspeptidase is distributed in the kidney, liver, pancreas and other parenchymal organs. γ - GT in the liver is mainly limited in the capillary bile duct and microsomes of liver cells, which can be used to diagnose space occupying liver diseases and liver parenchyma injuries (chronic hepatitis and cirrhosis).
2. Mild and moderate increases are mainly seen in viral hepatitis, cirrhosis, pancreatitis, etc.
3. γ - GT is also significantly increased in alcoholics, which can also be used to diagnose alcoholic liver disease.
4. The patients with obvious increase are found in primary or secondary liver cancer, hepatic obstructive jaundice, biliary cirrhosis, cholangitis, pancreatic head cancer, extrahepatic biliary tract cancer, etc.It has important diagnostic significance in judging whether patients with malignant tumor have liver metastasis and whether there is recurrence of liver cancer after operation.
5. In acute hepatitis, the decrease of γ - GT to normal is later than that of aminotransferase. If γ - GT continues to be higher, it indicates transposition of chronic liver disease;In chronic liver disease, especially in cirrhosis, γ - GT remains low, indicating a poor prognosis.
6. The specificity of γ - glutamyltranspeptidase as a liver cancer marker is low, and it can be increased in acute hepatitis, active chronic hepatitis, obstructive jaundice, biliary tract infection, cholelithiasis, and acute pancreatitis.
reference value
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Rate method: male 11~50U/L, female 7~32U/L.
matters needing attention
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Venous blood was taken at 12 hours on an empty stomach and collected in a red or yellow cap procoagulant tube.Reject hemolytic and fat blood samples.The time of binding and pressing the pulse belt should not be too long when collecting samples.
