经上皮电阻（TEER）测量装置
经上皮电阻（TEER）是指
特性
通过固定型电极可以进行稳定的测定 ad-MED比特利格尔 ® 通过与2（12孔用、24孔用）组合，可抑制测量值的变动，实现稳定的测量。 另外，电极的探针部分采用了耐腐蚀性强的材料。 可以在测量TEER值的同时添加被试验物质 通过固定型电极的狭缝结构，可以在插入物内添加被试验物质。 实时捕捉受试物质暴露带来的影响。 另外，通过安装市售的温度传感器，也可以监测培养基温度。 专用软件的经时测定、数据保存功能 通过在您的电脑上启动设备附带的专用软件，设定任意的测量间隔，可以进行经时的TEER值测量。 另外，测量的数据可以输出到CSV文件。
TEER值的测定方法
应用眼刺激性试验法“Vitrigel ®- EIT法“
论文使用实绩
Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals H. Yamaguchi, H. Kojima, T. Takezawa Journal of Applied Toxicology, 36(8), 1025-1037 (2016). Fabrication of a Corneal Model Composed of Corneal Epithelial and Endothelial Cells via a Collagen Vitrigel Membrane Functioned as an Acellular Stroma and Its Application to the Corneal Permeability Test of Chemicals H.Yamaguchi, T.Takezawa Drug Metabolism and Disposition, 46(11), 1684-1691(2018). Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing H.Kojima, H.Yamaguchi, T.Sozu, N.Kleinstreuer, L.Chae-Hyung, W.Chen, M.Watanabe, T.Fukuda, K.Yamashita, T.Takezawa Alternatives to Laboratory Animals, 47(3-4),140-157(2019).
Establishment of appropriate glaucoma models using dexamethasone or TGFβ2 treated three-dimension (3D) cultured human trabecular meshwork (HTM) cells M.Watanabe, Y. Ida, H.Ohguro, C.Ota, F.Hikage Scientific reports 11.1 (2021): 19369.
Novel microvascular endothelial model utilizing a collagen vitrigel membrane and its advantages for predicting histamine-induced microvascular hyperpermeability M.Uzu, T.Takezawa Journal of Pharmacological and Toxicological Methods, 106 (2020). A hybrid human microvascular endothelial cell line created by utilizing a cell fusion technique and its advantage for expressing high endothelial barrier function M.Uzu, T.Takezawa Nano Biomedicine, 14 (1), 9-17 (2022). Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation Lee CY, Wu SW, Yang JJ, Chen WY, Chen CJ, Chen HH, Lee YC, Su CH, Kuan YH. Arch Toxicol. 2024 Apr 18. doi: 10.1007/s00204-024-03751-0.
The Modulation of Respiratory Epithelial Cell Differentiation by the Thickness of an Electrospun Poly-ε-Carprolactone Mesh Mimicking the Basement Membrane. Choi, S. Y., Kim, H. J., Hwang, S., Park, J., Park, J., Lee, J. W., & Son, K. H. International Journal of Molecular Sciences, 25(12), 6650 (2024).
Porphyromonas gingivalis对人口腔粘膜上皮细胞影响的三维构建模型分析 笠孝成、内田邦敏、冈村和彦、八田光世、山崎纯、坂上龙资 日本牙科保存学杂志，63（2），144-155（2020）。
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