Biomarker Discovery and Validation

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 Biomarker Discovery解决方案 Types of Biomarkers Companion Products forBiomarker Discovery 资源，资源 接触规范
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Biomarker Discovery解决方案

Biomarker Discovery

Biomarkers provide vital information regarding safety and efficacy during drug discovery and development.Biomarkers can be classified as diagnostic，prognostic，or predictive and can be used to select patients for clinical trials or monitor patient response and treatment efficy.In addition，after regulatory，apval， biomarkers can be used to identify patient populations that would benefit from a particular therapy，and biomarkers can be used in clinical diagnostics to confirm the efficacy of a treatment and monitor long-term safety。

Biomarkers are used in research to design and develop more effective therapeutics，to assist in guiding decisions about which candidates to develop further，as surrogate markers for the selection of patients，and as endpoints for both benefits and risks.There are awide range of types of biomarkers，as endpoints for for for direct，diture as， prognostic，pharmacodynamic，safety，and efficacy markers.One class of biomarkers that is actively being researched is safety biomarkers.These markers are being developed to help determine which drug candidates are most likely to be safely tolerated in humans。

从发现到验证

Biomarkers range from specific molecules such as a protein，gene sequence，or expressed RNA to physiological parameters such as blood pressure or body temperature.They may be expressed in a specific location or tissue or found in serum，plasma，and other bodily fluids.Because of this diversity， most successful biomarker programs have a broad reach and investigate cellular，proteomic，and genetic sources inorder to find the most valuable biomarkers。

Validation of biomarkers requires that their levels change in response to a disease，condition，or other parameter in a consistent and statistically significant manner.Identification and characterization of biomarkers can reduce the number of candidate drugs that fail clinical trials，aid in the discovery of mothere，aputive， and provide methods for monitoring animals in preclinical research and evaluating the response of human participants in clinical trials。

Types of Biomarkers

  • Genomic Biomarkers

    Both gene expression and the presence of specific genetic sequences are used as biomarkers for many diseases including cancer.Treatments can even be tailored to an individual patient based on these genomic biomarkers.Typically， large-scale gene expression studies are conducted to identify genes that are up-or down-regulated in a particular indication or disease.These studies rely on the ability of the researchers to design exploratory and confirmatory panels as well as on powerful software tools to analyze resulting data and ifential。
    Genomic Biomarker发现»

  • Cellular Biomarkers

    The ability to uncover novel and rare cell types through multiparameter analysis allows researchers to characterize cell populations in greater detail and identify subpopulations that serve as markers for disease.Simple and reliable isolation of these cells fordownstream assays further supporther supports the cellbiomar foropulations for genomic and proteomic analysis。
    Cellular Biomarker发现»

  • Proteomic Biomarkers

    Interrogating biological samples to identify proteomic profiles gives rise to a plethora of potential biomarkers.Proteins are vital， functional parts of living organisms and as such reflect what is happening in that organism.Monitoring the post-translational state of proteins of interest canyield important biomarkers and indicate tumor progression。
    Genomic Proteomic Discovery»

Biomarker Discovery为Companion Products

  • Droplet Digital PCR（ddPCR）Systems，Reagents，and Assays

    • cancer therapies with high sensitivity and precision
    • Absolute quantitation removes the need for a standard curve and improves reproducibility
    • Inhibitor-tolerant reagents allow for analysis of more complex sample types

  • CFX Real-Time PCR检测系统

    • Powerful and flexible instruments with2-5颜色multiplexing to deliver sensitive，可重用detection of both single and multiplex real-time PCR reactions
    • High-throughput CFX Automation System can screen up to 84 plates in 24 hours
    • 使用状态表Reliance One-Step Multiplex RT-qPCR Supermix钢锭，钢锭，钢锭

  • 单中心序列工具

    • Study gene expression regulation with the SureCell ATAC-Seq Library Prep Kit and ATAC-Seq Analysis Toolkit
    • 可重复genome-wide profiling of the epigenomic landscape at the single-cell level
    • Validate scRNA-Seq studies as an orthogonal approach

  • ZE5 Cell Analyzer

    • Characterize the cellular universe using multiparameter cell analysis to identify and validate biomarkers
    • 监视器上30参数simultaneously，using上5 lasers，and identify cell subtypes faster and with more precision
    • 快速data acquisition rate allows rare or transient cell types to be analyzed
    • Small-particle detection to analyze biomarkers in exosomes

  • S3e Cell Sorter

    • Sort and analyze cells at your bench to support biomarker discovery and validation assays
    • 上方向3 lasers provide the flexibility needed to distinguish&sort subtly different cell populations
    • Cells are sorted quickly and gently while maintaining sensitivity and precision for downstream assays

  • Bio-Plex Multiplex Immunoassay System

    • Interrogate and quantify multiple proteins biomarkers in a single assay with a high sensitivity using xMAP technology
    • Generate biomarker expression data using off-the-shelf and custom screening assays
    • Conserve precious samples and use only~12.5µl of sample per multiplex assay

  • 电气和Western Blotting Tools

    • 锅炉炉膛炉膛水密封性能保证和保证
    • Achieve biomarker discovery data in hours vs days for traditional western blotting workflows
    • 分析expression of multiple potential biomarkers with multiplex imaging-chemiluminescence，fluorescence，or colorimetric

  • 防波堤，防波堤

    • 主、副、副、副、副、副、副、副、副、副
    • flow cytometry，ELISA，IHC，ICC，and western blotting
    • Explore biomarkers across Immunology，Cancer，Cell Biology，and more

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