Sarah A.Gagliano，ASHG:What is the focus of your research？
Dr.Zeggini:yresearch uses large-scale biomedical data to identify genetic causes of complex traits，with a primary focus on musculoskeletal diseases and cardiometabolic traits.Our activities are underpinned by the development of methods to advance statistical genetics approaches。
ASHG:你的位置是什么？
Dr.Zeggini:yundergraduate training in biochemistry gave me an excellent foundation to understand the complexties of biology.Early in my PhD work at the University of Manchester，I gained experience with wet-lab work，performing DNA extractions，HLA typing，and SNP and microsatellite genotyping。
Although this was definitely not my calling（or talent），experience in the lab has afforded me insights into what can go wrong in the experimental data generation process and how this can have a downstream impact on data analysis。
Ialso had quantitative training and developeda strong mathematical background through courses during my graduate and postgraduate studies，and through on-the-job training。
Finally，my postdoctoral work was in a highly collaborative environment，which was an important part of my training in“Team Science”—the interdisciplinary approach of engaging a group of individuals with varying expertise to tackle the same scientific question through diverse perspectives。
During my training，I never expected to be a part of work on the gender balance conundrum for careers in science.She currently leads the Wellcome Genome Campus Sex in Science program，which addresses this issue and supports women in science。
ASHG:What does a typical day at work usually entail？
Dr.Zeggini:I come into the office just after9am.My day typically includes a number of meetings with my team，local colleagues and/or wider collaborators.I have a couple of hours of protected meeting-free time in my diary daily，and try to keep one day afortnight completely free to work free from home。
I switch off my computer at5:30 pm（it stays at work），and tend to go back online late in the evening on my mobile device to check emails.I travel for work twice a month，on average.I find it an enriching experience，but do limit the number of nights away to a minimum。
ASHG:What are the most important skills to have for a career in genetics research？
Dr.Zeggini:
分析skills
Critical thinking skills
Ability to identify knowledge gaps and to frame research questions in the context of emerging technologies
钢锭到钢锭，钢锭到钢锭
Resilience
A sense of humour
ASHG:How do you achieve and maintain a healthy work-life balance？
Dr.Zeggini:Ienjoy great work-life balance，although this is a subjective assessment.I think it is important to recognize that there will be times when work takes precedence（inmy case this was especially true before children），and the other way around。
ASHG:在这里，我们可以看到？
Dr.Zeggini:Pick challenging scientific questions that excite you，and be open to learning the language of other disciplines and assimilate expertise that is new to you。
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