A-1210477 is a proteolytically stable，cell-permeable and high affinity BH3mimetics of anti-apoptotic protein MCL-1，binding to the target potently and selectively with a Ki value of 0.45nM，high ly selective against closely related proteins of BCL-2 nM，>1400-fold selectivity）。A-1210477 is the first-in-class small molecule MCL-1 inhibitor with sufficient potency to disrupt the tight-binding MCL-1-BIM complex in living cells，achieving the hallmarks of intrinsic apoptosis，and demonstrating clear-on-target cancer cell killing capability eitheras single single acagent nath in nath-AcentAxon3821）。

KEYWORDS:A-1210477｜Supplier｜Mcl-1inhibitor｜A1210477｜CT-A121｜CAS[1668553-26-1]｜Non Selective Mcl-1｜Inhibitor｜Proteins