Key points:
"Only when the body weight reaches more than 130 kg can the basic conditions for hematopoietic stem cell transplantation be met" is nonsense. In the clinical work of our hospital, from children weighing 30 kg to adults weighing 230 kg, there are successful cases of stem cell collection.
Verified by: Bai Bing, chief physician of Sun Yat sen University Cancer Center
Recently, a news report that # girls eat 4 steamed buns every day to transplant bone marrow for their mothers # made a hot search. It said that a 12-year-old girl needs to eat at least 4 steamed buns every day to transplant bone marrow for her mother, because the doctor said that she would need to gain 130 kg to be qualified for bone marrow transplantation. Many netizens were moved by the little girl's filial piety, but they also had some questions about the operation. Will human body weight affect hematopoietic stem cell transplantation? As a donor of stem cell transplantation, what are the precautions? For this reason, the Douzhen team specially invited Bai Bing, the chief physician of the Department of Internal Medicine of Sun Yat sen University Cancer Center, to answer questions for everyone.
1、 Under the premise of normal eating, digestion and absorption, the nutritional status has little impact on stem cells
First of all, hematopoietic stem cell transplantation includes two main links: stem cell collection and stem cell reinfusion. The "donor" in the stem cell collection process can be a healthy individual who meets the matching conditions (for allogeneic hematopoietic stem cell transplantation) or a patient himself (for autologous hematopoietic stem cell transplantation). The fattening girl mentioned in the article is the provider of allogeneic hematopoietic stem cell collection.
The effect of hematopoietic stem cell collection is affected by many factors, including: genetic constitution, age, organ function, stem cell mobilization mode, whether or not you have received surgery/chemotherapy/radiotherapy, the course and dose of chemotherapy/radiotherapy, nutritional status, etc. For a healthy hematopoietic stem cell donor, the number of stem cells mainly depends on genetic constitution, age and organ function. On the premise of normal eating, digestion and absorption, the nutritional status has little effect on stem cells.
The emphasis on weight in the news is actually a change of the concept of "weight" and "nutritional status". Although we often use weight to evaluate nutritional status in our life, nutritional status cannot be simply equivalent to weight. For individuals of different ages, genders and heights, weight has a corresponding normal range, which cannot be generalized.
2、 Body weight is not the only criterion for stem cell transplantation
The statement that "basic conditions for hematopoietic stem cell transplantation can only be met if the weight is more than 130 kg" is sheer nonsense. Weight is not the standard for stem cell transplantation. In the clinical work of Sun Yat sen University Cancer Hospital, from children weighing 30 kg to adults weighing 230 kg, there are successful cases of stem cell collection.
When does weight affect hematopoietic stem cells? For example, only when severe malnutrition (such as in war years, extreme poverty, life-threatening serious diseases, or long-term unscientific weight loss) leads to weight "significantly lower than the normal range of corresponding age, sex, and height individuals" can there be significant negative impact on stem cell collection, and then it is necessary to correct low weight. Even if it is corrected, it only needs to be corrected to the normal range, not beyond the normal range. The girls mentioned in the news do not meet the condition of "severe malnutrition". On the other hand, for a 12-year-old girl, it is obviously overweight to gain 130 kg.
3、 Deliberate weight gain is not only harmful to stem cells, but also harmful to health
Generally speaking, hematopoietic stem cells mainly exist in the red bone marrow, including the bone marrow cavity of long bones (such as humerus and femur) and the loose bone mesh of flat bones (such as iliac bone). What you gain in weight is actually adipose tissue, not hematopoietic stem cells.
The fattening will bring a variety of hazards, including cardiovascular disease, fatty liver, diabetes, bone and joint disease, cancer, etc. On the other hand, obesity also has a certain impact on self-confidence and mental health, and sometimes it may also bring difficulties in choosing jobs and spouses. Therefore, deliberate weight gain is absolutely harmful.
4、 As a donor of stem cell transplantation, what are the precautions?
After the matching is qualified, the stem cell collection process includes the injection of granulocyte stimulating factor, the monitoring of hematopoietic stem cell indicators in the blood, and the single collection on the computer. Generally, there is no special requirement. In terms of details, the doctor will inform you of specific precautions.
In conclusion, weight is not the standard for hematopoietic stem cell donors. If you deliberately gain weight, it will not increase hematopoietic stem cells, but will be harmful to your health. The statement in the article that "basic conditions for hematopoietic stem cell transplantation can only be met if the body weight is more than 130 kg" is inaccurate, which will mislead people to deliberately gain weight and endanger their health. On the other hand, there will be unnecessary doubts and concerns about the volunteers in the bone marrow bank.
Editor: fycfeng
click Tencent News APP search box, see [Truthful List] Every day, the latest rumor refutation and science popularization are completely eliminated.
Copyright notice: This article is a copy of Tencent's authentic copyright. Reproduction without authorization is prohibited. You are welcome to forward to your friends' circle and family group.