| 王洪豔，李兆新，邢麗紅，唐錫招.恩諾沙星及其代謝產物環丙沙星在牙鮃體內代謝消除規律.漁業科學進展，2014,35（3）：44-49 |
| 恩諾沙星及其代謝產物環丙沙星在牙鮃體內代謝消除規律 |
| Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in flounder Paralichthys olivaceus |
| 投稿時間：2013-08-23 修訂日期：2013-10-22 |
| DOI：10.11758/yykxjz.20140307 |
| 中文關鍵字： 恩諾沙星 環丙沙星 牙鮃 代謝消除規律 |
| 英文關鍵字： Enrofloxaxin Ciprofloxacin Flounder Pharmacokinetics |
| 基金項目：農業部財政專項“製定恩諾沙星在魚組織中最大殘留限量標準“和”鮃鰈魚類磺胺藥類代謝模式及種間評估”（2013A1002）課題共同資助 |
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| 摘要點擊次數： 12636 |
| 全文下載次數： 5571 |
| 中文摘要： |
| 以80 mg/kg魚體重對牙鮃單次口灌給藥恩諾沙星，給藥後在不同的時間點取樣，用高效液相色譜螢光檢測器檢測，研究恩諾沙星及其主要代謝產物環丙沙星在牙鮃體內的代謝消除規律。研究表明，停藥後0.25 h，肌肉中恩諾沙星殘留量最低。各組織的消除半衰期依次為腮>肝臟>血液>腎臟>肌肉，其中肌肉中恩諾沙星消除半衰期最低為67.759 h，消除最快，停藥後12 d檢測不到恩諾沙星。停藥後0.25 h，在牙鮃血液、肝臟、腎臟中均有環丙沙星殘留，殘留量依次為肝臟>腎臟>血液，肌肉和鰓中未檢出環丙沙星。停藥後22 d在血液、肝臟和腎臟3個組織中仍然能够檢測出恩諾沙星，但是停藥7 d後這3個組織中均檢測不出環丙沙星。結果顯示，恩諾沙星在牙鮃體內代謝速度較慢，而且只是在一段時間內有脫乙基代謝為環丙沙星的反應發生，但並不是在恩諾沙星消除的全過程都發生，而且代謝物環丙沙星在牙鮃體內的消除速度要比恩諾沙星快。 |
| 英文摘要： |
| In this study we investigated the pharmacokinetics and elimination of enrofloxacin（ENRO）and its metabolite ciprofloxacin（CIP）in Paralichthys olivaceus.After the oral administration of a single dose at 80 mg/kg•bw，the time courses of concentrations of ENRO and CIP in fish tissues were measured with high-performance liquid chromatography and a fluorescence detector.At 0.25 h，the muscle retained the lowest level of ENRO residues among five tissues（See below）.The elimination half-life of ENRO in the five tissues was in the order: gills＞liver＞kidney＞blood＞muscle.ENRO in muscle was eliminated fastest and had the lowest elimination half-life of 67.759 h；hence in the 12th day after the drug withdrawal，ENRO in the muscle was no longer detectable.At 0.25 h，the concentration of CIP residues in different tissues was in the order: liver＞kidney＞blood，while CIP could not be detected in the muscle and gills at the same time.In blood，liver and kidney，ENRO was still detectable in the 22nd day after the drug withdrawal；whereas CIP could not be detected in these tissues since the 7th day.These results indicated that the metabolism and elimination of ENRO in P. olivaceus was relatively slow.We also found that the degradation of ENRO into CIP occurred only in a short period after the ENRO administration.Obviously the elimination of CIP in flounder was much faster than that of ENRO. |
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