The cold pressing method is to place the drug and matrix powder in a cooling container, then put them into the mold of the suppository making machine, and extrude the suppository into a certain shape.
Cold compression method is suppository One of the commonly used preparation methods, or extrusion method. This method is suitable for the case where the main drug contained is unstable to heat or the suppository contains more components that are insoluble in the matrix. Compared with hot-melt method, this method can avoid the precipitation of insoluble components in the preparation process. However, this method requires special preparation machinery, and the shape of the suppository obtained is limited.
