There are many causes of bone and joint pain in the whole body, which are mainly found in the following aspects. First of all, if the elderly suffer from osteoarthritic pain, accompanied by enlargement of the joints, it is necessary to be alert to the possibility of osteoarthritis. Osteoarthritis is often related to age, calcium deficiency, and fatigue, which belongs to degenerative changes. However, young people have pain in their bones and joints, accompanied by swelling of joints. Especially if the small joints of their hands are obviously affected, they need to be alert to the possibility of rheumatoid arthritis, and some postpartum women will also have pain in their bones and joints. Therefore, we must go to the Rheumatology Department for relevant examinations, such as rheumatoid factor, anti cyclic citrulline antibody, erythrocyte sedimentation rate, and c-reactive protein, to clarify the specific reasons, and then we can take targeted drug treatment to avoid further aggravation of the disease.