At present, depression is mainly treated with antidepressants, psychological and behavioral therapy, and physical therapy. Especially for patients with moderate to severe depression and depression accompanied by psychotic symptoms, antidepressant drug treatment can often achieve good results. Antidepressants include new antidepressants and traditional antidepressants. The antidepressants currently used are mainly new antidepressants, including fluoxetine, paroxetine, citalopram, escitalopram, venlafaxine, and duloxetine. If one drug is not effective, two antidepressants with different mechanisms can be used together. In the process of treatment, synergistic drugs can also be added. In view of the obvious rejection of treatment and negative phenomena, it can increase electric shock treatment, that is, physical therapy, which can improve the depressive symptoms. After the improvement of depressive symptoms, we need to adhere to treatment for a period of time, and can increase psychotherapy to improve the treatment effect.