Many outpatients will complain about the pain in the palm joint. There are many reasons for the pain in the palm joint. If the body is regarded as a river, the pain in the palm joint is equivalent to a problem in the downstream of the river. Problems in the upstream and midstream of the river will cause changes in the downstream. For example, the upstream of the river is equivalent to the cervical spine, and there are diseases that compress the nerves such as cervical disc protrusion or cervical spinal canal stenosis, which often cause pain from the cervical spine to the palm joint. The middle reaches of the river are peripheral nerves, such as radial nerve, median nerve and ulnar nerve. When these nerves are injured, they will also cause joint pain in the palm. After judging the upstream and midstream of the river, we can analyze the downstream of the river, that is, whether there is a problem in the palm joint itself that causes pain. The answer is yes. For example, tenosynovitis of the palm and fingers, styloid tenosynovitis of the radius, and stenosing tenosynovitis can also cause pain in the palm joint, and even mild or moderate osteoarthritis may cause discomfort in the palm joint. Therefore, in case of palm joint pain, it is necessary to combine face-to-face clinical physical examination, and even cooperate with auxiliary imaging examination to determine what causes the palm joint pain.