Nephrotic syndrome often relapses. It can be prevented from various types of infection by slowly withdrawing the dose of glucocorticoid and treated with cytotoxic drugs. The common recurrence cause of nephrotic syndrome is related to the pathological type. 90% of patients with minimal change nephropathy are sensitive to glucocorticoid treatment, but the recurrence rate is as high as 60%. Therefore, for patients with minimal change nephropathy, in the process of hormone withdrawal, small doses should be maintained for a long time. In addition, infection is also the main reason leading to the recurrence of nephrotic syndrome and poor efficacy, which should be paid great attention to. Patients can prevent the occurrence of infection through a regular and healthy lifestyle, and patients with recurrent diseases can be treated with cytotoxic drugs to reduce the frequency of recurrence.