The occurrence of ankylosing spondylitis is mainly caused by the following factors: genetic factors. Modern research believes that the occurrence of ankylosing spondylitis is closely related to genetic factors, and there is an obvious phenomenon of family aggregation. People in this family carry human leukocyte antigen B27, and the gene will be passed down from generation to generation, and then they will get sick when encountering certain incentives. However, the disease is not necessarily caused by carrying this gene, which is 30 times higher than that of normal B27 negative patients. The main inducement is to feel the pathogenic wind, cold and dampness, or the infection of other parts of the body, such as gastroenteritis, urinary system infection, and female genital system infection as the inducement to induce the onset of ankylosing spondylitis.