There are several reasons for thigh cramp and fever: 1. Sprain. After sprain, it is easy to tear the thigh muscle. Inflammatory substances exude. cramp occurs because of pain, and fever occurs because of inflammatory infection. If there is no treatment or rest, it will cause a vicious circle and gradually worsen. 2. Tiredness can cause cramps and fever in the thighs, long standing, walking too much, climbing mountains, climbing stairs, etc. The muscles are always tired, and the patients will have cramps and inflammation exudation and fever. 3. Infection and bacterial infection will not only cause fever due to pus accumulation, but also cause muscle twitching, which will limit the activity. Blood routine examination, local ultrasound and magnetic resonance imaging are required. 4. Vascular diseases, thrombosis, including venous congestion, etc. Thrombosis can cause local cramps, fever, and inflammation. It needs to be checked clearly according to different conditions and treated symptomatically.