Creatine kinase is mainly located in myocardium, skeletal muscle and brain tissue, and the pathological changes in these three parts can lead to the increase of creatine kinase. Usually, when its value exceeds 1.5 times of the upper normal limit, it has clinical significance. The reasons for the rise of creatine kinase are as follows: 1. Myocardial disease. It includes myocarditis, myocardial infarction, acute heart failure, poisoning, electric defibrillation, coronary angiography or stent implantation leading to myocardial injury. 2. Skeletal muscle disease. It includes neurological diseases, myositis or toxic myopathy, muscle injury, muscle injection, rhabdomyolysis caused by alcoholism, hyperthermia, hypokalemia, intense exercise, generalized epilepsy, convulsions, and surgery. 3. Central nervous system diseases. Including subarachnoid hemorrhage, brain trauma, encephalitis, meningoencephalitis, etc. 4. Other diseases. Such as shock, pulmonary embolism, radiotherapy, lung, intestinal or prostate cancer, etc.
