Technetium methylene diphosphate is a complex formed by technetium stannous chloride and methylene diphosphate after reduction. It is mainly used for early diagnosis of malignant metastatic bone tumors and primary bone tumors. It has important value in survival detection of bone graft, diagnosis of traumatic fracture, bone inflammation, and metabolic bone disease. After application, this article should drink more water to accelerate the removal of radioactive drugs. Before examination, the patient should empty the bladder to reduce the detection of pelvic lesions covered by radioactivity in the bladder. During the application process, this substance is generally compatible with the drumbeat area of inflammatory lesions, and the required concentration will reach 5% 2 hours later. In addition, it can also be used for autoimmune diseases such as rheumatoid arthritis and orthopedic diseases. Generally, strict aseptic operation, intravenous injection, appropriate dose increase and prolonged treatment are better, but there may be local manifestations such as redness, swelling and rash.