The four plus signs of urine protein are relatively serious, indicating that the patient has a large amount of proteinuria. The formation of proteinuria is closely related to the barrier function of the glomerulus. The presence of proteinuria indicates that the glomerular filtration function is impaired. A large amount of protein loss is a typical symptom of kidney disease, which may be caused by glomerulonephritis, nephrotic syndrome, renal failure and other diseases. Long term urinary protein 4+is easy to cause hypoproteinemia, which is very serious. The patient also needs to further improve the 24-hour urine protein quantification, renal function, CT and other related examinations to clarify the cause. It is also necessary to do renal puncture biopsy to determine the specific pathological type, and then conduct targeted standardized treatment according to the pathological type. At the same time, patients need to pay attention to a low salt, low-fat, high-quality low protein diet. Pay attention to rest and avoid staying up late and fatigue.