Skin melanosis is a reversible disease, which is mainly treated symptomatically and will be better after recovery. Generally, avoid contacting with tar, petroleum, rubber products, cosmetics and other substances. Reduce ultraviolet radiation, pay attention to sunscreen, and avoid skin damage. Oral medicine can usually choose vitamin C, tranexamic acid tablets, compound glycyrrhizin capsules and complex vitamins. Melanosis is a pigmentation disease that occurs in mucous membrane or skin. Melanosis coli and melanosis facial skin are the most common, which are related to long-term constipation, taking anthraquinone laxatives, exposure to photosensitive substances and other factors.