The diagnosis of depression is clear and can be treated with antidepressants, psychotherapy and electric shock therapy. There are new antidepressants, including SSRIS and SNRIS, which represent fluoxetine, citalopram, paroxetine, venlafaxine and duloxetine. The old antidepressants include tricyclic antidepressants, such as imipramine and clomipramine, which have good therapeutic effects. If a drug has poor effect, antidepressants with different mechanisms can be used together. If antidepressants have poor effect, synergistic drugs can be added on the basis, including lithium carbonate, new antipsychotics and thyroxine tablets. For patients who refuse to eat, refuse to take medicine, and are more negative, electric shock treatment can be used. After the symptoms improve, continue to use antidepressants to maintain treatment. After the depressive symptoms are relieved, psychological treatment can be increased to enhance the therapeutic effect.