Once diabetic patients have urinary protein, they should be alert. Because at this time, if the diabetic nephropathy is allowed to further aggravate, it will eventually develop into uremia. If the urine tests were carried out continuously in the past six months, and the urinary protein excretion was 30 to 300mg twice a day, and other possible causes of increased urinary protein, such as diabetic hyperosmolality, ketoacidosis, urinary system infection, hematuria, hypertension, etc., were excluded, early diabetes could be diagnosed. At this stage, if effective prevention can be carried out, the urine protein can generally be turned negative. The common methods include diet control, blood sugar control and blood pressure control. If the protein can turn negative through these interventions, it is not a problem.