The treatment method of hepatitis B big three positive is determined according to the patient's specific condition, and it needs to be comprehensively formulated according to the liver function, hepatitis B DNA, liver B ultrasound, alpha fetoprotein and other related indicators. If there is abnormal liver function and it is considered to be caused by the activity of hepatitis B virus, the treatment is mainly divided into two aspects: liver protection and enzyme reduction and anti-virus. The antiviral oral drugs can choose entecavir and tenofovir. There are many drugs for liver protection and enzyme reduction, such as reduced glutathione, polyene phosphatidylcholine, glycyrrhizin preparations, etc., which can be used according to the condition of the patient. If the liver function and liver B ultrasound are normal, the patient is a virus carrier, and regular reexamination is the main method. The above scheme is only for reference. Please use the specific drugs under the guidance of professional doctors according to your own conditions.