If the patient's creatinine is high, kidney disease should be considered first. Creatinine is a metabolite of human muscle. Creatinine is mainly metabolized through the kidney. Therefore, if the glomerular filtration rate decreases, creatinine will rise. The reasons for high creatinine are as follows: 1. Severe exercise, high heat, dehydration and other reasons cause blood concentration and reduced renal blood flow, The decrease of glomerular filtration rate can lead to a transient increase of creatinine, which can be treated with fluid infusion, antipyretic, rest, etc. Creatinine can naturally return to normal. 2. Primary glomerular diseases, such as glomerulonephritis, can lead to the development of the disease and renal function damage, decrease of the glomerular filtration rate and increase of creatinine, which can be treated by creatinine lowering and protecting renal function. 3. Renal function damage caused by hypertension and diabetes, the decrease of glomerular filtration rate can increase creatinine, and treatment such as blood pressure control and blood sugar control can be given on the basis of improving renal function.