First of all, it is clear that rheumatism is not a disease, but a general term for a group of diseases, including a variety of inflammatory arthritis, such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriatic arthritis, gout arthritis, and so on. In addition, there are many reasons for knee pain, and a variety of rheumatism can cause knee pain. Many orthopedic diseases can also cause knee pain, such as meniscus injury, knee cartilage problems, such as anterior cruciate ligament injury and so on. Therefore, when knee pain occurs, it is necessary to first determine what causes the pain. If there are orthopedic problems, surgery may be required. Knee pain caused by rheumatic diseases should be treated differently according to their causes, such as knee pain caused by rheumatoid arthritis. Anti inflammation, detumescence, pain killing drugs and immunosuppressive drugs should be given, such as methotrexate, leflunomide, etc. If it is osteoarthritis, it should be given glucosamine, chondroitin sulfate and other cartilage protection drugs.