The etiology of advanced gastric cancer is still unclear, which may be related to diet, alcohol and tobacco addiction, fatty and greasy food, smoked and pickled food, chronic gastritis, chronic atrophic gastritis and other precancerous lesions, as well as infection with Helicobacter pylori and heredity. Advanced gastric cancer is relative to early gastric cancer. The early gastric cancer is limited to the mucosa and submucosa, while the advanced gastric cancer refers to the gastric cancer beyond the submucosa, which belongs to the advanced gastric cancer. Advanced gastric cancer requires not only surgical treatment, but also chemotherapy, radiotherapy, targeted treatment, traditional Chinese medicine and other comprehensive treatments after surgery.