First, allergic reaction and vascular edema, rash, pruritus, urticaria, and rare infiltration of eosinophils in the liver. Second, abnormal night dreams, hallucinations, excitement, irritability, insomnia. Third, sensory abnormalities, tactile disorders and seizures. Fourth, nausea, vomiting, dyspepsia, diarrhea, elevated transaminase, and rarely cholestatic hepatitis may occur. Fifth, muscle cramps may occur, such as myalgia, increased bleeding tendency, palpitations and edema.