The most common cause of lymphadenopathy is infection. The most common cause is cervical lymphadenitis, which is mainly secondary to the infection of the mouth or gums. At the same time, there will be fever. In serious cases, if there is acute suppurative lymphadenitis, manual incision and drainage are also required. The other is caused by malignant tumor. The development and fusion of tumor will also cause local redness, swelling, heat and pain similar to inflammatory changes, and local resection and biopsy can be selected to determine the pathological type and immunohistochemical results. Because of the enlargement of metastatic lymph nodes, the opportunity for radical resection is usually lost. After the pathology is obtained, systemic intravenous chemotherapy, biological immunotherapy or local radiotherapy can be selected to control the development of tumors. Lymph nodes belong to the defensive barrier of the human body, and many diseases will appear first. Therefore, if an unknown cause of lymph node enlargement is found, relevant auxiliary examinations should be carried out in a timely manner.