Human plasma mainly contains albumin and globulin. When the body exercises violently, has diarrhea, vomits or sweats heavily, it may lead to blood concentration and protein increase. In addition, diseases can also lead to the increase of albumin or globulin in plasma. For example, chronic liver diseases, autoimmune diseases, chronic inflammation and chronic infection, multiple myeloma, macroglobulinemia, etc. Relevant examinations need to be improved as soon as possible to clarify the etiology.