In case of gradual hardening and itching, external drugs can be used for improvement. Hand eczema is divided into acute eczema, subacute eczema and chronic eczema. Generally, only chronic eczema will harden. If the symptoms gradually turn into chronic eczema. In terms of topical drugs, it is necessary to choose some topical ointment containing acidic ingredients for treatment. It is suggested that when applying compound lactic acid cream, it can be treated with Tenide cream or directly applied with fluticasone propionate cream. In this way, it can not only soften the skin lesions, but also play a therapeutic role. Then, in our daily life, we should pay attention not to frequently use alkaline liquid or irritant liquid to clean the itchy skin, otherwise it may lead to the aggravation of the original disease symptoms.