What medicine should I take for sore tongue? The following diseases are common for sore mouth and tongue: the first is recurrent oral ulcer, which has the characteristics of anti aggressive attack, red and yellow time pain. Generally, we can relieve the symptoms by applying glucocorticoid locally and systematically. The second disease is herpetic gingival stomatitis, which can cause large blisters on the tip of the oral mucosa, ulceration and swollen gums. We also have systemic antiviral treatment locally to alleviate the symptoms. The third case is traumatic oral ulcer, that is, there are many residual roots and crowns in the mouth, which repeatedly stimulate the oral mucosa to form ulcers. By sharpening the edge of the teeth, pulling out the residual roots, and taking a little anti-inflammatory and analgesic orally, the symptoms disappear. So you should go to the hospital to have a detailed examination of the sores on your mouth and tongue, see what causes them, and deal with them accordingly.