The causes of edema in diabetic patients mainly include the following aspects: First, diabetic nephropathy will produce a lot of proteinuria, leading to the decrease of plasma albumin and edema, which is the most common reason; 2、 Diabetic patients with severe heart failure, peripheral venous congestion, reduced blood flow back to the heart, will also appear edema; 3、 The abnormal liver function caused by any reason reduces the ability of liver to synthesize protein. Diabetic patients are often prone to combine viral hepatitis, alcoholic liver disease, autoimmune liver disease, etc., which may lead to hypoproteinemic edema; 4、 Diabetic patients with hypothyroidism will lead to mucinous edema of the whole body; 5、 Diabetic patients who take thiazolidinedione antidiabetic drugs or CCB antihypertensive drugs combined with hypertension may have drug-related edema.