Urticaria often occurs at night, which may be related to the allergen of the indoor environment or the mental state of the patient, such as the allergy to the materials contacting the bedding and pillow core, or whether there is dust mite allergy around the bedding and pillow, or the indoor temperature allergy, as well as the mental tension and allergy of the patient. Urticaria often shows wheal damage to the skin and flushing and edema damage to the skin mucosa. The skin lesions can subside within 24 hours, accompanied by itching. Urticaria, also known as rubella mass, is a common allergic disease of skin and mucous membrane, which is characterized by a transient localized edema rash with severe itching. Most patients are caused by allergy. Common allergic factors include food, drugs, infection, inhalation, physical and chemical factors, friction, pressure, genetic factors, mental factors, etc. The disease often starts with skin itching, followed by red and pale wheals. The wheals vary in size, shape, and number. They can occur suddenly, often fade within 24 hours, leaving no traces, and recur repeatedly. They rise one after another, with no fixed location. They can affect the respiratory tract, digestive tract, cardiovascular system, and can be accompanied by headache, dyspnea, nausea, vomiting, abdominal pain, and diarrhea, In severe cases, symptoms such as laryngeal edema, asphyxia and anaphylactic shock may occur. The patient should remove the inducement of urticaria and take anti allergic treatment.