The blister on the foot accompanied by obvious itching is probably a fungal infection of the foot. Fungal infection of the foot, also known as tinea pedis, is mainly manifested as erythema, papules, blisters, desquamation and obvious itching. You can use a microscope to do a microscopic examination of fungi to see whether there are pathogenic hyphae or spores. If mycelium is found, tinea pedis should be considered. Antifungal ointment can be used, such as amoroven, terbinafine, bifonazole, etc. Of course, in daily life, we should pay attention to personal hygiene, avoid cross infection, and keep our feet dry, which can inhibit the reproduction of fungi.