The urethral orifice is tingling when urinating, indicating that there must be inflammation at the urethral orifice. The urethral orifice should be checked for redness, swelling and secretion. If there is secretion, it is recommended to do smear inspection of the secretion to check whether there are bacteria, fungi, mycoplasma, chlamydia, gonococci, etc. It is suggested that everyone drink a lot of water, urinate more, pay attention to the hygiene of the urethral orifice, or eat sodium bicarbonate to alleviate the symptoms of urethral tingling. The type of antibiotics to be used should be determined according to the test results. Levofloxacin, roxithromycin, doxycycline, cefdinir, etc. are generally recommended for treatment, which can treat common bacterial infections. In case of gonococcal infection, ceftriaxone sodium is recommended. In case of non gonorrhea infection, azithromycin is recommended.