The reason for hand swelling after getting up in the morning may be the diseases of the renal system, mainly including acute nephritis, chronic nephritis, acute interstitial nephritis, chronic interstitial nephritis, rapid progressive nephritis, etc. It can also be a secondary renal system disease, mainly including diabetic nephropathy, lupus nephritis, hepatitis B related nephropathy, etc. At the same time, the possibility of hand swelling caused by other diseases should be excluded, mainly including edema caused by hypothyroidism drugs, edema caused by allergy, cardiac insufficiency, liver insufficiency, etc. In case of hand swelling in the morning, it is recommended to see a doctor in a regular hospital. Routine urine test, 24h UP quantitative test, blood biochemistry, coagulation system and other tests can be improved to make a clear diagnosis and give active and reasonable treatment.