There are many skin diseases with purpura, which are generally classified as vascular system diseases and coagulation disorders, but they are often the result of multiple factors. Here are some of the reasons, such as thrombocytopenia, abnormal platelet function and thrombocytosis, coagulation diseases, such as genetic diseases. The use of anticoagulants vitamin K deficiency, protein c deficiency, protein s deficiency, liver failure and other vascular causes, such as abnormal blood protein cold globulinemia. Physical factors of blood vessel, such as the increase of pressure in blood vessel, the decrease of supporting tissue around blood vessel, the abnormality of vascular system, etc. It may also be related to virus, and various acute and chronic infections or virus infections may also cause the occurrence of purpura.