High thyroid stimulating hormone may cause damage to various systems, including cardiovascular system, digestive system, endocrine system, etc. High thyroid stimulating hormone is common in subclinical hypothyroidism or clinical hypothyroidism. The hypothyroidism caused by various reasons leads to systemic hypometabolic syndrome, which is mainly manifested as myxedema. With the continuous disturbance of thyroid hormone level, it may cause damage to various systems, such as memory decline, slow reaction, muscle weakness, bradycardia, anorexia, abdominal distention, female menorrhagia or amenorrhea, etc., and even myxedema coma in serious cases. After the diagnosis, it is necessary to regulate the thyroid hormone level with standardized medication.