The pressure difference of blood pressure refers to the difference between systolic pressure and diastolic pressure. The greater the difference in blood pressure, the worse the elasticity of the great arteries, which is the manifestation of arteriosclerosis, is more common in some elderly people and atherosclerosis. For hypertensive patients with large blood pressure difference, calcium antagonists such as nifedipine, amlodipine, and lecardipine can be selected as antihypertensive drugs. In addition, ACEI and ARB antihypertensive drugs can also be selected, such as valsartan, benazepril, etc. In addition, diuretics such as hydrochloroxazine can also be used. If there is high blood fat and diabetes, we should actively reduce blood fat and blood sugar to reduce arteriosclerosis.